Introduction: The degree of osseointegration determines the long-term survival and favorable outcomes of orthopedic implant use. Initial fixation is influenced by a number of factors. Hydroxyapatite (HA) coating has a good osteoconductive property and sealing effect on peri implant migration of particles that lead to osteolysis. Furthermore, HA-coated implants show desirable midterm clinical re...

Successful small-molecule antibacterial agents must meet a variety of criteria. Foremost is the need for selectivity and safety: It is easy to kill bacteria with chemicals, but difficult to do it without harming the patient. Other requirements are possession of a useful antibacterial spectrum, no cross-resistance with existing therapeutics, low propensity for rapid resistance selection, and pha...

OBJECTIVES To describe the use of antibacterials among outpatients in Norway and to explore patterns of age- and gender-specific use. METHODS Data were extracted from the Norwegian Prescription Database (NorPD), a complete register of all dispensed prescriptions in Norway, in the period 1 July 2005-30 June 2006. NorPD contains data at an individual level. We extracted patients who had receive...

OBJECTIVES The goal of this study was to evaluate the effects of DNA and F-actin [polyanions present in high concentration in cystic fibrosis (CF) airway fluid] on the antibacterial activities of the cationic steroid antibiotic CSA-13 and the cationic peptides LL37, WLBU2 and HB71. METHODS Light scattering intensity was used to evaluate the aggregation of DNA and F-actin by the cationic antib...

We have examined several neurochemical and behavioural parameters related to the function of the mesolimbic dopamine (DA) pathway in animals treated with nicotine following three modes of drug administration, i.e. systemic intraperitoneal injection, intra-accumbens (Acb) infusion or intraventral tegmental area (intra-VTA) microinjection. The present modes of systemic, intra-Acb and intra-VTA ni...

Smart Hydrogels Article 2201286 by Yiyun Cheng, Jianru Xiao, Jingjing Hu, and co-workers, reports a type of smart hydrogel simply mixing aminoglycoside antibiotics cellulose nanocrystals. The prepared hydrogels show excellent rheological behavior allow facile administration spraying. In addition, the gels exhibit efficient antibacterial activity both in vitro vivo accelerate healing bacteria in...

Janthinocins A, B and C are novel antibacterial agents produced by Janthinobacterium lividum. They were isolated from fermentation broths and characterized by UV, IR, NMR and mass spectroscopy. They are cyclic decapeptide lactones with marked activity against aerobic and anaerobic Gram-positive bacteria and are 2 to 4 times more potent in vitro than vancomycin. Janthinocins A and B were also fo...

The susceptibility of Streptococcus mutans to chlorhexidine and to six commonly used, systemic antibacterial agents (amoxicillin, cefuroxime, penicillin, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin) was studied for 424 clinical isolates from 116 children and students. The MIC of chlorhexidine for all isolates was < or = 1 micrograms/ml. No resistance to the other antimicrobial...

The mechanisms underlying cerebral vasodilatation during hypercapnia are not fully understood. To examine the role of nerves and prostaglandins in the regulation of basal blood flow and in hypercapnia-induced vasodilatation in the cerebral blood vessels of rabbit.Cerebral blood flow was measured by laser Doppler flow-meter in 18 NZW rabbits anesthetized with sodium pentobarbital.  Tetrodetoxin ...

A 63-year-old female with candidemia following necrotizing pancreatitis developed clinical signs of chorioretinitis and underwent the systemic administration of voriconazole, after which anterior chamber inflammation and multiple, white, fluffy, chorioretinal lesions, under 1mm in diameter, were gradually resolved and visual acuity improved. We report the first Korean case of candida chorioreti...