Virtual windows could improve the elderly’s health and emotional state. Therefore, this study aims to identify and understand the concept of the virtual window in the elderly’s living environment. To achieve this purpose, this study summarizes the concept of the virtual window for the elderly’s windowless living environment. Then, based on this concept, this study proposes syntheses of the virt...

In this study, a series of syntheses was conducted on the pyrimidine system, obtaining bisulfite carboxyl derivatives 4 and hydroxy derivatives 5. In addition, a series of syntheses were carried out as a result of which both alkyl and aromatic amines were obtained. Then, the attempt was made to cyclize these amines in the Mannich reaction to pyrimido[4,5-d]pyrimidines 11, 12. After determinatio...

V-ATPase has recently emerged as a promising novel anticancer target based on extensive in vitro and in vivo studies with the archazolids, complex polyketide macrolides which present the most potent V-ATPase inhibitors known to date, rendering these macrolides important lead structures for the development of novel anticancer agents. The limited natural supply of these metabolites from their myx...

A full account of the enantioselective total syntheses of (+)-lyconadin A (1) and (-)-lyconadin B (2) is presented. Central to this venture was recognition and deployment of a key strategy-level intramolecular aldol/conjugate addition cascade that led, in a single operation, to two new carbon-carbon sigma-bonds, three new stereogenic centers, and two new rings, albeit with the incorrect stereog...

Derinamycin was isolated from the myecelium of Streptomyces venezuelae Tü 1102 and its molecular formula was tentatively assigned as C51H93NO23. The antibiotic inhibits the growth of fungi, gram-positive bacteria and certain gram-negative bacteria but is less acitve against yeasts. A study of derinamycin action on the macromolecular synthesis of intact Bacillus subtilis revealed that the anti...

The mode of action of cryomycin upon Staphylococcus aureus IFO 3061 and Bacillus subtilis IFO 3037 has been investigated. Cryomycin inhibited the syntheses of protein, RNAand DNAto almost the same degree. It caused a rapid increase of endogenous and exogenous respiration in the test organisms at minimumgrowth inhibitory concentrations. It was concluded that the primary effect of cryomycin was o...

a highly practical and efficient preparation of pyrano[3,2-c]pyridone and pyrano[3,2-c]quinoline derivatives was developed via an ionic liquid mediated and promoted multi-component reaction of malononitrile, aldehyde, and 4-hydroxyquinolin-2(1h)-one or 4-hydroxy-6-methylpyridin-2(1h)-one. the combinatorial syntheses were achieved for the first time without applying extra activation energy at am...

The Diels–Alder (DA) reaction is regarded as quite a useful strategy in organic and macromolecular syntheses.