Huntington disease (HD) is a monogenic that results in combination of motor, psychiatric and cognitive symptoms. HD caused by CAG trinucleotide repeat expansion the huntingtin ( HTT ) gene, which production pathogenic mutant protein (mHTT). Although there no cure at present for HD, number RNA-targeting therapies have recently entered clinical trials aim to lower mHTT through use antisense oligo...

| Four-quadrant synapse stuu In our rst treatments of single-transistor synapses ((1], 2]; elaborated in 3]), we presented the electron-tunneling, hot-electron{injection, and multiplicative behavior of these devices. We used a feedback connguration to characterize the tunneling and hot-electron injection phenomena in these synapses 3]. We also derived an eeective learning rule, but we did not c...