This randomized crossover trial study was designed to investigate the relationship between exercise intensity, sweat rate and sweat sodium and potassium concentrations of trained endurance athletes in order to determine sodium and potassium losses and therefore requirements. Eighteen male endurance athletes (age 37.9±9.7 y, weight 83.2±13.6 kg, VO2 max 60.8±9.4 mL/kg.min -1) were randomized int...

BACKGROUND The phenotypic spectrum of cystic fibrosis (CF) has expanded to include patients affected by single-organ diseases. Extensive genotyping and nasal potential difference (NPD) testing have been proposed to assist in the diagnosis of CF when sweat testing is inconclusive. However, the diagnostic yield of extensive genotyping and NPD and the concordance between NPD and the sweat test hav...

Sweat glands are abundant in the body and essential for thermoregulation. Like mammary glands, they originate from epidermal progenitors. However, they display few signs of cellular turnover, and whether they have stem cells and tissue-regenerative capacity remains largely unexplored. Using lineage tracing, we here identify in sweat ducts multipotent progenitors that transition to unipotency af...

Objective. Sweat collected for testing should have quantity not sufficient (QNS) rate of ≤10% in babies ≤3 months of age. Michigan (MI) cystic fibrosis (CF) centers' QNS rates were 12% to 25% in 2009. This project was initiated to reduce sweat QNS rates in MI. Methods/Steps. (a) Each center's sweat testing procedures were reviewed by a consultant. (b) Each center received a report with recommen...

Sweat-gland carcinoma is a rare cutaneous appendage malignant tumor. Primary sweat-gland cancer can arise in the eyelid and orbit and is extremely rare. It has been classified into different types, and is usually locally recurrent after surgery. The tumors also appear in the orbit, which is characterized by metastasis. Therefore, great attention should be paid to the development of sweat-gland ...

—— In this work a robust, non-invasive and wearable micro-fluidic system was developed and employed to analyse pH of sweat in real time during exercise. The device is incorporated in an optical detection platform designed to provide real-time information on sweat composition. The device has been tested by monitoring the pH of sweat during 55 minutes of cycling activity. During these trials, the...

Chloride concentrations in sweat were measured by "vacancy liquid chromatography," a technique in which anions eluting from an ion-exchange column in the presence of an elution buffer which absorbs at 280 nm cause a decrease in absorbance proportional to the concentration of the anion. Less than 1 microL of sweat suffices for this analysis, which takes 5 min per sample. Results were comparable ...

Amino acids were measured by ion-exchange liquid chromatography in sweat samples obtained from 22 healthy men during sauna bathing. Amino acids were also measured in plasma (collected before breakfast) and urine (24-h collections) from the same subjects. Serine, ornithine, citrulline, and aspartic acid were present in sweat in mean concentrations >10-fold their mean concentrations in plasma. In...

BACKGROUND Cystic Fibrosis (CF) is a potentially lethal genetic disorder. The most frequent mutation worldwide in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene is designated as the Delta F508 mutation. This mutation was found in only 33% of Pakistani patients studied. Since the common Pakistani mutations remain to be identified, appropriate screening tools are required to ...

BACKGROUND Patients with familial dysautonomia (FD) manifest episodic hyperhidrosis despite the reduction of sudomotor fibres and sweat glands associated with this autonomic neuropathy. We assessed peripheral sudomotor nerve fibre and sweat gland function to determine if this symptom was due to peripheral denervation hypersensitivity. METHODS In 14 FD patients and 11 healthy controls, direct ...