BACKGROUND The clinical impact of arrhythmias on the continuum of critical illness is unclear, and data in medical intensive care units (ICU) is lacking. In this study, we distinguish between different types of arrhythmias and evaluate if their distinction is of clinical importance based on ICU length of stay and mortality outcomes. METHODS We performed a retrospective analysis of 215 patient...

All current 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors [simvastatin (SV), lovastatin (LV), atorvastatin, pravastatin, fluvastatin, and cerivastatin] are believed to undergo an atypical -oxidation of the dihydroxy heptanoic or heptanoic acid side chain. Metabolites, which are shortened by twoand/or four-carbon units consistent with -oxidation products, have been reported exclusively in ...

BACKGROUND Recent studies have demonstrated sagittal spinal balance was more important than coronal balance in terms of clinical result of surgery for adult spinal deformity. Notably, Schwab reported that one of the target spinopelvic parameters for corrective surgery was that pelvic incidence (PI) minus lumbar lordosis (LL) should be within +/- 10 °. The present study aimed to investigate whet...

Retrotransposons constitute over 40% of the human genome and play important roles in the evolution of the genome. Since certain types of retrotransposons, particularly members of the Alu, L1, and SVA families, are still active, their recent and ongoing propagation generates a unique and important class of human genomic diversity/polymorphism (for the presence and absence of an insertion) with s...

The reduced-gravity environment in space is known to cause an upward shift in body fluids and thus require cardiovascular adaptations in astronauts. In this study, we recorded in rats the neuronal activity in the subthalamic cerebrovasodilator area (SVA), a key area that controls cerebral blood flow (CBF), in response to partial gravity. "Partial gravity" is the term that defines the reduced-gr...

I appreciate the insight provided by this letter to the authors regarding the issue of sagittal malalignment in this case report. Although the case report was directed at the postoperative seroma and potential relationship with the use of vancomycin, andwas not related to the sagittal alignment per se, the input provided in this case ismuch appreciated. In fact, I went back and remeasured the p...

Submitted for the MAR14 Meeting of The American Physical Society Unidirectional alignment of block copolymer templated porous films using solvent vapor annealing with soft shear ZHE QIANG, KEVIN CAVICCHI, BRYAN VOGT, The University of Akron — Porous films templated by block copolymers (BCPs) have been extensively investigated due to their potential numerous applications such as sorbents and nan...

Simvastatin (SV) is a semisynthetic derivative of lovastatin (LV), which biosynthetically produced from the fungus Aspergillus terreus and has high log p value (log = 4.39)and thus hepatic extraction efficacy in controlling cholesterol synthesis. The current study was undertaken to investigate metabolic profile SV using various mass spectrometry (MS) platforms. Metabolic profiling studied vitro...