نتایج جستجو برای: sustained virologic response
تعداد نتایج: 1043902 فیلتر نتایج به سال:
he rapid development of new Tantiviral drugs for hepatitis C (HCV) and the availability of interferon (IFN)-free and soon ribavirin-free treatment regimens of 12 weeks duration with sustained virologic response (SVR) rates of >90% has stimulated predictions that HCV will be eradicated. This commentary discusses the impact of these new treatments in different regions of the world and the barrier...
Methods We identified a cohort of IDUs receiving care at the Pender Community Health Centre on Vancouver’s Downtown East Side. Potential subjects were identified as either never having been infected with HCV (noninfected arm), having spontaneously cleared the virus (spontaneous arm), or having achieved a sustained virologic response on antiviral treatment (SVR arm). A questionnaire to identify ...
BACKGROUND Chronic hepatitis C has great impact on world's health. Current therapy for genotype 1 hepatitis C virus includes protease inhibitors boceprevir and telaprevir, associated to standard therapy - peginterferon alfa + ribavirin. There are no published data in Brazil on the results of this new therapy, and it is interesting an evaluation of what was accomplished up to this moment. Object...
Abbreviations: CHC, chronic hepatitis C; CYP, cytochrome P450; HCV, hepatitis C virus; IL, interleukin; Peg, pegylated interferon alfa; RBV, ribavirin; SVR, sustained virologic response; VDRs, vitamin D receptors; Th, helper T cell; 25(OH)D, 25-hydroxyvitamin D; 1,25(OH)D, 1,25-dihydroxyvitamin D Corresponding author: Tae Yeob Kim Department of Internal Medicine, Hanyang University Guri Hospita...
نتایج درمان ترکیبی با اینترفرون و ریباویرین در بیماران مبتلا به هپاتیت مزمن C ، براساس ژنوتایپ ویروس
Background and purpose: About 200,000 of Iranian population are infected with Hepatitis C Virus. On the basis of Iranian consensus on management of chronic hepatitis C (CHC) infection in 2004, combination therapy with conventional α-Interferon (IFN) plus Ribavirin is the first therapeutic choice in CHC patients. Data are limited on treatment response rate in most areas of the country. To asse...
Molecular tests that detect and/or quantify HCV RNA are important in the diagnosis and management of patients with chronic hepatitis C (CHC) undergoing anti-viral therapy. The primary goal of anti-HCV therapy is to achieve a sustained virologic response (SVR) defined as "undetectable" Hepatitis C Virus (HCV) RNA in the serum or plasma at 12 to 24 weeks following the end of treatment.
Efforts to develop novel, interferon-sparing therapies for treatment of chronic hepatitis C (HCV) infection are contingent on the ability of combination therapies consisting of direct antiviral inhibitors to achieve a sustained virologic response. This work demonstrates a proof of concept that coadministration of the nucleoside analogue MK-0608 with the protease inhibitor MK-7009, both of which...
Danoprevir (DNV) is a hepatitis C virus (HCV) protease inhibitor that achieves high sustained virologic response (SVR) rates in combination with peginterferon alfa-2a-ribavirin in treatment-naive HCV genotype 1 (G1)-infected patients. This study explored the efficacy and safety of ritonavir-boosted DNV (DNVr) plus peginterferon alfa-2a-ribavirin in G1-infected prior peginterferon-ribavirin null...
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