INTRODUCTION Imatinib mesylate is an antineoplastic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional imatinib mesylate (Gleevec) tablets produce rapid and relatively high peak blood levels and requires frequent administration to keep the plasma drug level at an effective range. This might cause side effects, reduced effectiveness and poor thera...

With this notice, we alert readers that Frontiers has received two messages questioning the soundness of the experimental results of the publication “Water hyacinth: a possible alternative rate retarding natural polymer used in sustained release tablet design” published on 11 June 2014 in Frontiers in Pharmacology. Our Chief Editors, Prof. Theophile Godfraind and Dr. Dominique Dubois, will dire...

In present study, mucoadhesive vaginal tablet of sertaconazole was designed using a combination of mucoadhesive polymers like Carbopol 934P, chitosan, carboxymethylcellulose sodium, sodium alginate, methyl cellulose, hydroxypropyl methylcellulose and hydroxypropyl cellulose. Effervescent was incorporated into formulations to enhance swellabilty of mucoadhesive tablet. For various drug-free form...

The manufacture of bi-layer tablets, produced by the sequential compaction of loose powder layers has recently become of increased interest within the pharmaceutical industry due to the tailored release profiles of active ingredients that may be obtained. In a bi-layer configuration, the immediate release layer of the bilayer tablet has worked as the loading dose and the sustained release layer...

Levofloxacin effervescent sustained release tablets were developed in eight different formulations (F1 to F8) by employing different grades of polymers and effervescent agents such as sodium bicarbonate and citric acid. The formulations were evaluated for various physical parameters, dissolution parameters and drug released mechanisms. F8 formulation showed maximum floating time of 12 hours and...