SUSTAIN (Supervised and Unsupervised STratified Adaptive Incremental Network) is a network model of human category learning. This paper extends SUSTAIN so that it can be used to model unsupervised learning data. A modified recruitment mechanism is introduced that creates new conceptual clusters in response to surprising events during learning. Two seemingly contradictory unsupervised learning d...

Stimulation of cells with physiological concentrations of calcium-mobilizing agonists often results in the generation of repetitive cytoplasmic Ca(2+) oscillations. Although oscillations arise from regenerative Ca(2+) release, they are sustained by store-operated Ca(2+) entry through Ca(2+) release-activated Ca(2+) (CRAC) channels. Here, we show that following stimulation of cysteinyl leukotrie...

Despite quercetin (QC) promising features for cancer therapy, low solubility, poor permeability, and short biological half-life time significantly confine its application in therapy. In this study, a novel approach is developed to improve loading efficiency attain sustained-release concurrently. direction, hydrogel nanocomposite of agarose (AG)-polyvinylpyrrolidone (PVP)-hydroxyapatite (HAp) wa...

Neurotransmitter release following synaptic vesicle (SV) fusion is the fundamental mechanism for neuronal communication. Synaptic exocytosis is a specialized form of intercellular communication that shares a common SNARE-mediated fusion mechanism with other membrane trafficking pathways. The regulation of synaptic vesicle fusion kinetics and short-term plasticity is critical for rapid encoding ...

Recently, it was proposed that secretory vesicles have widely varying Ca(2+) thresholds for exocytosis. This model can explain adaptation of secretory responses and predicts that incomplete release is a consequence of insufficient Ca(2+). However, membrane capacitance-based measurements have not supported varying Ca(2+) thresholds. Here, Green Fluorescent Protein (GFP) imaging is used to test w...

The aim of the work was to develop Theophylline hydrochloride sustain release tablet using Methocel k 15 MCR, Methocel K100M CR premium and Methocel K4M CR premium in blending and granulation stage of processing and evaluate their physico-chemical properties and also compared the dissolution profile with the marketed drugs.Tablets were prepared by wet granulation method. The active ingredient, ...

The aim of this study was to prepare zopiclone-loaded polycaprolactone microspheres by emulsion solvent evaporation technique with different drug-to-carrier ratios {MP 1 (1:1), MP 2 (1:2), MP 3 (1:3), and MP 4 (1:4)}, characterize and evaluate the in vivo performance. The microspheres were characterized for particle size, surface morphology, drug excipient compatibility, percentage yield, drug ...