We recently demonstrated Solvent Immersion Imprint Lithography (SIIL), a rapid benchtop microsystem prototyping technique, including polymer functionalization, imprinting and bonding. Here, we focus on the realization of planar polymer sensors using SIIL through simple solvent immersion without imprinting. We describe SIIL's impregnation characteristics, including an inherent mechanism that not...

Molecular imprinting involves the synthesis of polymers in the presence of a template to produce complementary binding sites with specific recognition ability. The technique has been successfully applied as a measurement and separation technology, producing a uniquely robust and antibody-like polymeric material. Low molecular weight molecules have been extensively exploited as imprint templates...

Synthetic receptors for phosphates and phosphonates have been generated in SiO2 xerogels via a surface molecular imprinting method. The monomer 3-trimethoxy silylpropyl-1-guanidinium chloride (1) was developed to prepare receptor sites capable of binding with substrates through a combination of ionic and hydrogen bond interactions. HPLC studies and adsorption isotherms performed in water have f...

Capacitive biosensors belong to the group of affinity biosensors that operate by registering direct binding between the sensor surface and the target molecule. This type of biosensors measures the changes in dielectric properties and/or thickness of the dielectric layer at the electrolyte/electrode interface. Capacitive biosensors have so far been successfully used for detection of proteins, nu...

We have engineered a class of colloids which can recognize the shape and size of targeted microbial cells and selectively bind to their surfaces. These imprinted colloid particles, whichwe called “colloid antibodies”, were fabricated by partial fragmentation of silica shells obtained by templating the targeted microbial cells. We successfully demonstrated the shape and size recognition between ...

We report on a simple and effective process that allows direct imprinting of microand nanostructures on non-flat surfaces using flexible polymer stamps. Pattern imprinting was tried using a UV-curable polymer blend containing poly(propylene glycol) diacrylate, trimethylolpropane triacrylate and a photoinitiator. The UV-resist was dispensed manually on convex and concave surfaces of a glass lens...

Heparin-imprinted synthetic polymer surfaces with the ability to attenuate activation of both the complement and the coagulation system in whole blood were successfully produced. Imprinting was achieved using a template coated with heparin, a highly sulfated glycosaminoglycan known for its anticoagulant properties. The N,N'-diacryloylpiperazine-methacrylic acid copolymers were characterized usi...

Molecular imprinting finds relevance and importance in a range of applications including the development of new chemical sensors, separation technologies, and selective binding particularly for catalytic and bioreactors. While molecular imprinting technology has found success when imprinting small molecules, progress in molecular imprinting of biomacromolecules, such as polypeptides and protein...

The authors developed a new technique to create micro-and nanometer scale structures on curved free-standing objects by combining embossing/imprinting lithography approaches with mechanical loadings on elastic films. Embossing/imprinting generates small structures and mechanical loading determines shape or geometry of the final object. As a result, a portion of the tubes with a radius between 0...

The environmental pollution of 2,4,6-tribromophenol (TBP) has attracted attention. Based on an urgent need for the better provision of clean water, in situ determination of TBP is of great importance. Here, a facile and effective approach for detecting TBP is developed, based on coupling molecular imprinting technique with electrodeposition of chitosan (CS) on the gold electrode. The TBP imprin...