نتایج جستجو برای: suppressor

تعداد نتایج: 46590  

Journal: :Current Drug Targets 2014

Journal: :The Journal of clinical investigation 1980
T Miller E Marshall

Infection-induced anergy is a frequent complication of bacterial, viral, and parsitic infection. A marked suppression of the thymus-derived (T) lymphocyte response to concanavalin A has been demonstrated in vitro during renal infection and the mechanisms by which suppression occurs have been investigated. In particular we have considered the possibility that suppression might result from the in...

2013
Paolo Sansoni Earl D. Silverman Manzoor M. Khan

One mechanism of histamine-mediated inhibition of the immune response in man is to activate T suppressor cells that bear the Leu 2 (OKT8) marker. The current study was undertaken to characterize the histamine-induced suppressor cell using a monoclonal antibody (9.3) shown previously to distinguish cytotoxic T cells from antigen-specific suppressor T cells. Leu 2+ cells isolated from peripheral ...

2003
ROBERT A. GOOD

The functional role of suppressor cells in the control of the immune response has now been recognized. This phenomenon may soon be considered an essential aspect of immunity. The role of antigen-specific and nonspecific suppressor lymphocytes in the regulation of antibody production has been demonstrated (1). In vivo experiments have suggested the existence of suppressor cells in some forms of ...

Journal: :Cellular immunology 1977
J R Oehler R B Herberman D A Campbell J Y Djeu

Normal rat spleens contain suppressor cells which can inhibit proliferative and cytotoxic responses of lymphocytes to alloantigens ijz vitro. The suppressor cells are adherent, phagocytic, resistant to treatment with ATS and C, radioresistant, resistant to treatment with mitomycin C, apparently absent from the thymus, and found in very high concentrations in peritoneal exudates. These character...

Journal: :The Journal of Experimental Medicine 1981
J S Bromberg B Benacerraf M I Greene

Intravenous injection of 0.01 mM 2,4,6-trinitrobenzene sulfonic acid-derivatized syngeneic lymphoid cells generates a Thy-1-positive, antigen-specific suppressor cell for contact sensitivity which requires an I-J allogeneic effect to become fully activated. It is necessary and sufficient for all allogeneic effect to be directed solely against the suppressor cell, and once activated, the cell ca...

Journal: :Journal of leukocyte biology 2015
Thomas Condamine Jérôme Mastio Dmitry I Gabrilovich

Myeloid-derived suppressor cells are a heterogeneous group of pathologically activated immature cells that play a major role in the negative regulation of the immune response in cancer, autoimmunity, many chronic infections, and inflammatory conditions, as well as in the regulation of tumor angiogenesis, tumor cell invasion, and metastases. Accumulation of myeloid-derived suppressor cells is go...

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