Background Despite considerable progress in the development of cellbased therapies, targeted delivery to specific tissues particularly those deep in the body where direct injection is not possible has been problematic. Here we show that tumour-conditioned macrophages infected with oncolytic HSV Seprehvir display a classic activated (M1) profile characterized by the expression of pro-inflammator...

background: finding a suitable method for rapid, accurate and reliable estimation of absorbed dose has high priority in management of the radiation exposed persons. shortly after radiation exposure, apoptosis is a major detriment in proliferative tissues such as the hematopoietic system. therefore, quantification of apoptosis in these tissues could be useful for rapid estimation of radiation ex...

Determining the electronic structure of actinide complexes is intrinsically challenging because inter-electronic repulsion, crystal field, and spin-orbit coupling effects can be of similar magnitude. Moreover, such efforts have been hampered by the lack of structurally analogous families of complexes to study. Here we report an improved method to U≡N triple bonds, and assemble a family of urani...

In the past decades, there is a growing interest in the design and synthesis of composite microspheres with a dielectric solid sphere (e.g., silica, polystyrene) covered by metallic and their corresponding metal oxides shell, such as copper[1], gold[2], silver[3,4], iron oxide[5], zinc oxide[6,7], titanium oxide[8,9] and zirconium dioxide[10]. Such materials may exhibit a few unique electrical,...

Cancer is a disease caused by an uncontrolled division of abnormal cells in a part of the body. It is a major cause of death, and its incidence is increasing every day. Various methods and protocols used which include chemotherapy, radiology, surgical removal of the tumor, etc. But these methods have many side effects that make patients feel unbearable pain and inflict deep anxiety. Over the pa...

Purpose The utility of (super)paramagnetic agents to enhance contrast in MRI has been for some time demonstrated in human studies. The contrast provided by these agents arises from their ability to achieve reductions in T1 and T2*. Another approach to designing contrast agents is to consider the use of ultrasound (US). We have developed a method involving the application of US in MRI in the pre...

With the discovery of the phenomenon of single-molecule magnetism, coordination chemists have turned their attention to synthesizing cluster aggregates of paramagnetic ions. This has led to a plethora of coordination clusters with various topologies and diverse magnetic properties. In this paper, we present ways of describing and understanding such compounds as well as outlining a new approach,...

The paramagnetic Meissner eeect (PME), in which the eld-cooled-magnetization (FCM) of superconducting samples is positive below the super-conducting transition temperature T c , has been observed in certain ceramic and single-crystal samples of the high-T c cuprate superconductors and more recently in disk-shaped Nb samples. Through systematic investigations of the conditions for observing the ...

Introduction: Magnetic particle imaging (MPI) is a method capable of determining the spatial distribution of super-paramagnetic iron oxide particles (SPIOs) at potentially high sensitivity, high spatial and high temporal resolution [1,2,3]. The feasibility of a single-sided coil arrangement for field generation and reception of the particle signal was shown in [4]. There, the object of interest...

The possibility of a new technique for fabricating nanoparticles from thin films using selective oxidation in an atmosphere mixture of water vapor and hydrogen was investigated. Fe-5wt.%Al films were RF-sputtered and annealed in the atmosphere mixture at 900°C for up to 200 min, in order to oxidize aluminum selectively. Thermodynamics simulation showed that temperatures exceeding 800°C are nece...