recent studies in animal models indicate that recombinant human erythropoietin (rhepo) is very effective in enhancing neurological recovery after spinal cord injury (sci). we aimed to evaluate the effect of rhepo plus methylprednisolone sodium succinate (mpss) compared to mpss alone to improve neurological function of patients after sci in a randomized clinical trial. during a 15-month period 3...

the activities of 4-aminobutyric-2-oxoglutaric acid transaminase (gaba-t) and succinate semialdehyde dehydrogenase (ssadh) were determined in mouse hypothalamus after peripheral injections of cholecystokinin-8 (cck-x)and/or caerulein (cln). gaba transaminase activity was measured utilizing endogenous succinate semialdellyde dehydrogenase to convert the product of gab a-t, succinate semialdehyde...

Serotonin is a naturally occurring “messenger” protein that is found primarily in the gastrointestinal system, certain blood cells (platelets) and the central nervous system (brain and brain stem). Abnormal activity of this messenger protein has been implicated in both migraine and depression, and medications that modify serotonin can be effective in treating both disorders. Such medications in...

OBJECTIVE To compare the efficacy of 20 mg of IV metoclopramide, given up to four times over 2 hours as needed for persistent headache, with 6 mg of subcutaneous sumatriptan for the emergency department treatment of migraine headaches. METHODS This was a randomized, double-blind, clinical trial with two intervention arms. The primary endpoint was change in pain intensity as measured by an 11-...

BACKGROUND During the interdigestive state in humans, erythromycin 40 mg induces a premature activity front that starts in the stomach, while erythromycin 200 mg induces a prolonged period of enhanced antral contractile activity. AIMS To study the involvement of a cholinergic pathway in the motor effects of erythromycin using the muscarinic antagonist atropine and the neural 5-HT1 receptor ag...