OBJECTIVES The study was undertaken to evaluate the burn wound healing property of oil of Cocos nucifera and to compare the effect of the combination of oil of Cocos nucifera and silver sulphadiazine with silver sulphadiazine alone. MATERIALS AND METHODS Partial thickness burn wounds were inflicted upon four groups of six rats each. Group I was assigned as control, Group II received the stand...

OBJECTIVES The in vitro pharmacodynamics of silver(I) and silver(II) complexes of a polydiguanide ligand, chlorhexidine, were assayed to examine the value of the bactericidal endpoint as an alternative means of evaluating their antibacterial activities against burn wound pathogens. METHODS Synthesis of silver(I) chlorhexidine [Ag(I)CHX] was accomplished by in situ precipitation of the complex...

Acute therapy with pyrimethamine plus sulfadiazine is the treatment of choice for reactivated toxoplasmic encephalitis (TE). Acute therapy is followed by lifelong maintenance therapy (secondary prophylaxis) with the same drugs at lower dosages. The use of pyrimethamine plus sulfadiazine is hampered by severe side effects including allergic reactions and hematotoxicity. Alternative treatment reg...

It has been claimed that trimethoprim, 2,4diamino 5 (3',4',5' trimethoxybenzyl)pyrimidine, exerts a "synergistic" effect when combined with sulfonamides (Hitchings, Drugs, Parasites and Hosts, p. 202, J. and A. Churchill, Ltd., London, 1962) and polymyxin (Garrod and Waterworth, J. Clin. Pathol. 15:328, 1962) in experimental infection of mice and natural 0.5 ml of a 5% suspension of granular ho...

Silver, platinum, gold, stainless-steel, and copper electrodes were used with low currents (0.02 to 20 muA/mm(2)) to explore their electrochemical effects on the growth of four bacterial species. In the higher current ranges, all electrodes inhibited growth at both poles, usually in conjunction with electrolytic break-down of the medium and severe corrosion of the metal. Silver, however, was ex...

The saprophytic bacterium Serratia plymuthica was recovered from a facial wound (burn) site of a pediatric patient. The clinical significance of the organism was undetermined due to its apparent eradication from this location by therapy with topical 1% silver sulfadiazine. Seeding of the burn with S. plymuthica may have occurred from contaminated moisture sometimes found on and around steam rad...