نتایج جستجو برای: suicide gene
تعداد نتایج: 1164769 فیلتر نتایج به سال:
The efficacy of HSV-1 thymidine kinase (TK) and Escherichia coil cytosine deaminase (CD) suicide gene therapies as cancer treatments are currently being examined in humans. We demonstrated previously that compared to single suicide gene therapy, greater levels of targeted cytotoxicity and radiosensitization can be achieved in vitro by genetically modifying tumor cells to express CD and HSV-1 TK...
objective: the aim of this study was to better understand the triggers of suicide, particularly among the ancient greek and persian soldiers and commanders. method: ‘herodotus: the histories’ is a history of the rulers and soldiery who participated in the greco-persian wars (492-449 bce). a new translation (2013) of this manuscript was studied. accounts of suicide were collected and collat...
Background: One of the important aspects of the epidemiologic study of suicide and its related behaviors is the identification of suicide methods. This study aimed to investigate the geographical epidemiology of common methods of suicide and suicide attempts in Fars Province located in Southwestern Iran during the years 2010-2013. Materials and Methods: The present study was conducted on 17,...
We have demonstrated antitumor activity against refractory human glioma and pancreatic tumors with 6-methylpurine (MeP) using either a suicide gene therapy strategy to selectively release 6-methylpurine in tumor cells or direct intratumoral injection of 6-methylpurine itself. A single i.p. injection in mice of the prodrug 9-beta-D-[2-deoxyribofuranosyl]-6-methylpurine (MeP-dR; 134 mg/kg) caused...
Objectives Suicide is a major cause of death worldwide, especially among teens and adolescents. The aim of this research was the structural test of the Interpersonal Theory of suicide model in Students. Methods Suicide is a major cause of death worldwide, especially among teens and adolescents. The aim of this research was the structural test of the interpersonal theory of suicide model in st...
the aim of this study was to evaluate suicide probability in iranian males with substance abuse or dependence disorder and to investigate the predictors of suicide probability based on trait mindfulness, reasons for living and severity of general psychiatric symptoms.participants were 324 individuals with substance abuse or dependence in an outpatient setting and prison. reasons for living ques...
Tumor cells harbor a repertoire of unique, mutated antigens and shared self-antigens but generally are incapable of provoking an effective immune response, likely because of inadequate antigen presentation by professional antigen-presenting cells. Heat shock proteins (HSPs) play important roles in eliciting innate and adaptive immunity by chaperoning peptides for antigen presentation and provid...
A major obstacle to the success of gene therapy strategies that directly target cancer cells is the low gene transfer rate. To address this problem, we had previously proposed a combination adenoviral gene therapy containing a conditionally replicating adenovirus (CRAD) expressing mutant E1 (Delta24RGD), and a replication-defective E1-deleted adenovirus to enhance the efficiency of gene transfe...
Suicide is a global public health problem with particular resonance for the US military. Genetic risk factors for suicidality are of interest as indicators of susceptibility and potential targets for intervention. We utilized population-based nonclinical cohorts of US military personnel (discovery: N = 473 cases and N = 9778 control subjects; replication: N = 135 cases and N = 6879 control subj...
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