BACKGROUND Bipolar disorder (BPD) is the Axis I disorder with the highest risk for coexisting substance use disorder. One explanation for this phenomenon is the 'self-medication hypothesis', which states that some patients experience improvement in psychiatric symptoms as a result of substance use. We thus investigated reasons for substance use and perceived substance-induced improvement in BPD...

Anxiety sensitivity (AS) has been linked to both pathological anxiety and substance use problems. We evaluated relations between AS and substance use situations among individuals with substance use disorders (SUDs) and concurrent DSM-IV anxiety disorders. We predicted that AS would be most strongly associated with substance use in situations involving negative emotions and interpersonal conflic...

The intra-arterial infusion of substance P produced dose-related responses of both parotid and submandibular salivary secretion in anesthetized rats. The substance P-induced secretion in both glands was inhibited by the substance P analogues [D-Arg1, D-Trp7.9, Leu11]-substance P and [D-Arg1, D-Pro2, D-Trp7.9, Leu11]-substance P, but not by [D-Pro2, D-Trp7,9]-substance P. The profiles of protein...

conclusions the results of this study in terms of personality disorders and types of used drugs were in accordance with the previous studies results. it is necessary to design appropriate treatment plans for medical treatment of those with personality disorders. results there was a significant correlation between stimulant use and histrionic personality disorder (p < 0.001) and antisocial and n...

background: several studies have shown that attentional bias plays a role in the beginning, persistence and relapse of substance abuse disorder. therefore, identifying the factors related to attentional bias in substance abusers is important. in so doing, the present study was aimed at examining the relationship between attentional bias, anxiety sensitivity and metacognitive beliefs in substanc...