Several recent papers argue that due to the slowing down of Dennard’s scaling of the supply voltage future multicore performance will be limited by dark silicon where an increasing number of cores are kept powered down due to lack of power. Customizing the cores to improve power efficiency may incur increased effort for hardware design, verification and test, and degraded programmability. In th...

A single amino acid mutation near the active site of the CAPN5 protease was linked to the inherited blinding disorder, autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, OMIM #193235). In homology modeling with other calpains, this R243L CAPN5 mutation was situated in a mobile loop that gates substrate access to the calcium-regulated active site. In in vitro activity assays, ...

Uveitis is a potentially blinding inflammatory disease. Thirty to 50% of uveitis cases are considered idiopathic. The present study sought to determine the intraocular cytokine patterns in the different etiological types of uveitis in order to better understand their immunological regulation and to determine whether the cytokine pattern may be a useful diagnostic tool. From a multicenter instit...

granuloma annulare is self-limiting cutaneous condition of unknown etiology, causing necrobiotic dermal and subcutaneous papules. a number of conditions have been described in association with granuloma annulare , including lymphoma, anemia, intestinal bleeding, seronegative arthralgia, vasculitis and autoimmune thyroiditis. this manuscript, as the first report of this combination in iran, desc...

We report a case of IgG4-related disease presenting both tubulointerstitial nephritis and retroperitoneal fibrosis causing acute renal failure in a 63-year-old male. He was admitted to our hospital because of acute renal failure requiring emergent hemodialysis. Computed tomography showed a soft-tissue density mass with an irregular border in the retroperitoneum. The mass involved bilateral uret...

Aims: To determine if neural elements are present in sub-and epiretinal PVR membranes as well as in diabetic, fibrovascular membranes removed from patients during vitrectomy surgery. Methods: Human sub-and epiretinal membranes of varying durations were immunolabeled with different combinations of antibodies to GFAP, vimentin, neurofilament protein and laminin. Results: Anti-neurofilament labele...

Vitrectomy was performed on 25 eyes in 21 patients with chronic uveitis from various etiologies. Postoperative follow up averaged 22.8 months with visual improvement in 24 of 25 eyes. In this retrospective study, the techniques employed and the beneficial effect of vitrectomy alone or vitrectomy combined with cataract surgery (Iensectomy in most cases) on improving vision and decreasing th...

Background: Quantitative measurements of vitreous inflammation using vitreous/retinal pigment epithelium-relative intensity (VIT/RPE-Relative Intensity) have been described recently. In proliferative vitreoretinopathy (PVR), plays a central role in the pathogenesis, inducing retinal fibrosis and contraction. However, no attempts yet to be made analyze severity PVR pr...