Subclinical hypothyroidism, defined as a mild degree of thyroid dysfunction biochemically, is a common clinical disease. It is marked by elevated serum concentrations of thyroid stim‐ ulating hormone (TSH) and normal serum concentrations of free thyroxine (fT4) and triiodo‐ thyronine (T3). Subclinical hypothyroidism can be divided into two categories, depending on the magnitude of the increase ...

Calcific aortic valve disease (CAVD) is a progressive disorder that encompasses a spectrum of valve pathologies ranging from calcification of valve leaflets to obstruction of blood outflow. Early subclinical stages of CAVD are characterized by aortic valve calcification (AVC), which has historically been considered a benign degenerative condition that occurs with advancing age but is now recogn...

Subclinical hypothyroidism (SCH) is a common disorder that is characterized by elevated thyroid-stimulating hormone levels in conjunction with free thyroxine concentrations within the normal reference range. Thyroid hormones are known to affect the heart and vasculature and, as a result, the impact of SCH on the cardiovascular (CV) system has recently become an important topic of research. Stro...

Expansion of a GGGGCC repeat in C9orf72 causes amyotrophic lateral sclerosis, frontotemporal dementia, or a combination of both. Bidirectional repeat transcripts sequester RNA-binding proteins into nuclear RNA foci. The repeat is translated into dipeptide repeat (DPR) proteins that are crucial for repeat-induced toxicity. DPRs inhibit the proteasome and sequester other proteins. These changes a...