The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC(50)] approximately 0.15 microM), while dihydrousambarens...

Abstract Loganiaceae is a member of the Gentianales order and comprises about 460 species in 16 genera, being mainly distributed tropical regions world. The Brazilian Neotropical region one centers diversity for two richest genera Loganiaceae, Spigelia Strychnos, justifying floristic efforts to better understand family this region. This study aims update taxonomic knowledge state Pernambuco, No...

BACKGROUND Protein cross-linking which occurs towards the latter part of protein glycation is implicated in the development of chronic diabetic complications. Glycation induced protein cross-linking inhibitory effects of nine antidiabetic plants and three spices were evaluated in this study using a novel, simple, electrophoresis based method. METHODS Methanol extracts of thirteen plants inclu...

The aim of the study was to investigate the possibility of improving the therapeutic efficacy of the total alkaloid fraction (TAF) extracted from processed nux vomica by reducing the strychnine contents. Most strychnine was removed from TAF to obtain the modified total alkaloid fraction (MTAF). The toxicity and pharmacokinetics of TAF and MTAF were further investigated and compared besides thei...

This study aimed to evaluate the sleep modulating properties of Strychnos spinosa and innocua fruits in Swiss albino mice. The depressant effect extracts on central nervous system was studied using a diazepam-induced model mice were divided into four groups six each. test received at doses 250, 500, 1000 mg/kg body weight intraperitoneally. In contrast, control group distilled water 10 ml/kg. D...