Experimental evidence suggests that proteins adsorbed to hydrophobic surfaces at low coverages are stabilized relative to the bulk. For larger coverages, proteins unfold and form beta-sheets. We performed computer simulations on model proteins and found that: 1), For weakly adsorbing surfaces, unfolded conformations lose more entropy upon adsorption than folded ones. 2), The melting temperature...

Structural stability ensures that the qualitative behavior of a system is preserved under small perturbations. We study it for planar bimodal linear dynamical systems, that is, systems consisting of two linear dynamics acting on each side of a given hyperplane and assuming continuity along the separating hyperplane. We describe which one of these systems is structurally stable when (real) spira...

The introduction of a small amount of bounded rationality into a model sometimes has little effect, and sometimes has a dramatic impact on predicted behavior. We call a model robust to bounded rationality if small deviations from rationality result only in small changes in the equilibrium set. We also say that a model is structurally stable if the equilibrium set (given fully rational agents) v...

The tree-structured wavelet transform has received a lot of attention and has found successful applications in signal denoising, image coding, image analysis, etc. In this paper, we present an analysis of the structural stability of the tree-structured wavelet transform, a topic which has not been addressed properly in previous research. We also present a texture classification algorithm based ...

TK (transketolase) undergoes inactivation during biocatalytic processes due to oxidation, substrate and product inhibition, reactivity of aldehyde substrates, irreversible inactivation at low pH, and dissociation of cofactors. However, the contribution of protein denaturation to each of these mechanisms is not fully understood. The urea-induced reversible denaturations of the apo- and holo-enzy...

A systematic approach to study the phase stability of LiBH4 based on ab initio calculations is presented. Three thermodynamically stable phases are identified and a new phase of Cc symmetry is proposed for the first time for a complex hydride. The x-ray diffraction pattern and vibrational spectra of the Cc structure agree well with recently reported experimental data on LiBH4. Calculations of t...

Statement I hereby confirm that this thesis is my own work and that I have documented all sources used. Acknowledgements First of all I would like to express my gratitude to Prof. Dr. Hans-Peter Lenhof, who provided me with a relevant and challenging subject to work on. Whenever needed he was available for guidance and support, including questions unrelated to the topics of this thesis. was an ...

The enhanced stability of a mesophilic metalloprotein was assessed using biophysical spectroscopies. Significant local structural interconversions during thermal insult account for a reorganization of the protein scaffold, without disturbing the active metal site. This cushioning mechanism is proposed to be a generic property of metalloproteins contributing to enhanced stability.

Subject of this contribution is to develop a framework for assessment of collaborative networks (CN) structural stability on the stage of the CN design. CN design is a critical source of competitive advantage given that as much as 80% of total product cost may be fixed by these decisions. The importance of the stable CN structuring is evident. The elaborated framework aims to develop a techniqu...