The readiness with which many organisms develop resistance to streptomycin is well recognized; Willcox (1953) ventured to predict that "should streptomycin be widely used for gonorrhoea it is possible that its efficiency may decline". At the Liverpool Royal Infirmary during the past 4 years routine treatment of male patients suffering from gonorrhoea has been by a single injection of streptomyc...

Streptomycin, the antibiotic produced by Streptomyces griseus, contains as a part of its structure a diguanidine derivative of scyllo-inositol called streptidine. Two major precursors of the streptidine portion of the molecule have now been defined, n-arginine and n-glucose (1, 2). Arginine plays a role in the formation of the guanidine side chains, whereas glucose is involved in the synthesis ...

The following is a report on the effect of streptomycin in twenty-one suitable cases of tuberculosis treated in the Hardinge Hospital (Dharampore and Arcadia Dharampore) during the year 1948. Clinical material.?All patients in this series had pulmonary tuberculosis which, prior to streptomycin therapy, had not responded to bedrest or other accepted forms, of treatment. There was roentgenographi...

Streptomycin is an aminocyclitol glycoside antibiotic, which interferes with prokaryotic protein synthesis by interacting with the ribosomal RNA. We report here that streptomycin is also able to inhibit self splicing of the group I intron of the thymidylate synthase gene of phage T4. The inhibition is kinetically competitive with the substrate guanosine. Streptomycin and guanosine have in commo...

Richardson, Marvis (Michigan State University, East Lansing) and Jane N. Holt. Synergistic action of streptomycin with other antibiotics on intracellular Brucella abortus in vitro. J. Bacteriol. 84:638-646. 1962.-It has been found that streptomycin acts synergistically with penicillin and tetracycline to inhibit the growth of Brucella abortus within bovine cells cultured in vitro. Extracellular...

Acute treatment with 300 mg/kg of pigmented guinea pigs with streptomycin sulfate induces an elevation of endogenous fluorescence in vestibular ampullary cristae. Fluorescence accumulates in all compartments of the epithelium, i.e., vestibular sensory and supporting cells and nerve fibers of the stroma and it was very intense 1 and 12 hours after its administration. Fluorescence decreased to co...

Various reports (l-5) have demonstrated that streptomycin inhibits the metabolic activities of the non-proliferating cells of susceptible strains of bacteria. This paper is an attempt to trace the mode of action of streptomycin with the object of determining what reactions vital to the cell are interfered with. Study of the mode of action of the antibiotics of therapeutic value should eventualI...

Sermonti, G. (Istituto Superiore di Sanità, Rome, Italy), Milena Bandiera, and Isabella Spada-Sermonti. New approach to the genetics of Streptomyces coelicolor. J. Bacteriol. 91:384-392. 1966.-Mixed cultures of complementary auxotrophic strains of Streptomyces coelicolor A3(2) were preincubated on discs of cellophane on complete medium and were then transferred onto selective media. When one st...

Viomycin-resistant strains isolated from Mycobacterium smegmatis demonstrated pleiotropic resistance to tuberactinomycin-N, capreomycin, streptomycin, and kanamycin as a result of mutational alteration of ribosomes, even though they were selected for resistance to a single antibiotic. The pleiotropic drug resistance of three mutants isolated by stepwise selection for resistance to viomycin was ...