To the Editor: In pneumococci, resistance to fluoroquinolones is associated with chromosomal mutations in the quinolone-resistance–determining regions (QRDR) of type II topoiso-merase enzymes, predominantly gyrA and parC. Several mutations have been described in these enzymes, but only a few have been shown by in vitro studies to confer resistance: S81F or Y, C, or I and E85K in gyrA; E474K in ...

Streptococcus Pneumoniae suspension preparation S. Pneumoniae capsular type 6A (DBL6A) was previously described as a virulent strain (Briles et al., 1992). Hemoculture of mouse second passage isolates were provided by Dr. Denis Martin (ID Biomedical, Quebec, Canada) and a suspension of the provided culture in Todd Hewitt medium supplemented with 0.5% yeast extract (THY) was incubated at 37 o C ...

Streptococcus pneumoniae (pneumococcus) remains a major cause of mortality and morbidity at the extremes of age. With increasing antibiotic resistance, its accurate early identification is important for initial management [1]. Its identification in clinical laboratories relies on colony morphology, α-haemolysis on blood agar, and optochin susceptibility. The bile solubility test, although simpl...

With the development of penicillin, Streptococcus pneumoniae has become an uncommon cause of bacterial endocarditis in adults. Subacute manifestation of pneumococcal endocarditis has been reported a few times in the literature, but most reports define the disease as acute, severe, and having a high mortality rate. We report the case of a 58-year-old male with subacute bacterial endocarditis due...

The in vitro activity of A-56268 was determined and compared with that of erythromycin and clindamycin against a limited spectrum of 401 gram-positive and gram-negative organisms. A-56268 was quite active against erythromycin-susceptible Staphylococcus aureus, Neisseria gonorrhoeae, Listeria monocytogenes, Streptococcus pneumoniae, Streptococcus pyogenes, and group B streptococci and was modera...

Objetivo. Caracterizar macroscópica y microscópicamente las lesiones causadas por Streptococcus pneumoniae en muestras de pulmón cuyes (Cavia porcellus) crianza intensiva Lima. Materiales métodos. Se hizo la necropsia 138 con signos clínicos neumonía, se tomó muestra los pulmones afectados. realizó el aislamiento bacteriano para identificación pneumoniae, utilizando agar sangre pruebas bioquími...

A 45-year-old man with HIV infection (CD4 count of 6 cells per cubic millimeter) presented after 2 days of diminishing visual acuity and pain in his right eye. Examination revealed a corneal ulceration and hypopyon (Fig. 1, white arrow). Chest radiograph demonstrated right lower lobe pneumonia. Cultures of the hypopyon, sputum, and blood grew Streptococcus pneumoniae. The patient was treated wi...

An historical account is presented of attempts to establish the serologic identity of Lister's pneumococcal capsular Groups T and V.