In sickle cell disease (SCD), hemoglobin molecules polymerize intracellularly and lead to a cascade of events resulting in decreased deformability and increased adhesion of red blood cells (RBCs). Decreased deformability and increased adhesion of sickle RBCs lead to blood vessel occlusion (vaso-occlusion) in SCD patients. Here, we present a microfluidic approach integrated with a cell dimension...

Background: Reduced deformability of red blood cells (RBCs) may play an important role on the pathogenesis of chronic vascular complications of diabetes mellitus. However, available techniques for measuring RBC deformability often require washing process after each measurement, which is not optimal for dayto-day clinical use at point of care. The objectives of the present study are to develop a...

BACKGROUND AND DESIGN In this study we set out to determine the effects of long-term physical training on hemorheological, laboratory parameters, exercise tolerability, psychological factors in cardiac patients participating in an ambulatory rehabilitation program. METHODS Before physical training, patients were examined by echocardiography, tested on treadmill by the Bruce protocol, and bloo...

three-dimensional surface geometry of rock discontinuities and its evolution with shearing are of great importance in understanding the deformability and hydro-mechanical behavior of rock masses. in the present research, surfaces of three natural rock fractures were digitized and studied before and after the direct shear test. the variography analysis of the surfaces indicated a strong non-line...

Deformability of resealed erythrocyte membranes was measured by using an ektacytometer. Divalent anti-spectrin antibody, but not monovalent anti-spectrin Fab fragments, decreased membrane deformability. Membranes resealed with MgATP were more deformable than those without MgATP. Exogenous alkaline phosphatase, which dephosphorylates spectrin, decreased membrane deformability. These results sugg...

Membrane rigidity has been widely accepted as the dominant cause of reduced deformability both of ATP-depleted erythrocytes and erythrocytes containing excess calcium (Ca). However, recent studies have shown normal membrane deformability in ATP-depleted erythrocytes. In addition, Ca accumulation causes massive ion and water loss, and it has been shown that extensive dehydration causes an increa...

dual systems of steel moment frame and reinforced concrete shear wall have combined the advantages of steel frames and reinforced concrete shear wall. these walls have increased the lateral stiffness of steel frames and have reduced seismic demands on steel frames thus providing opportunities to use such system. in this research intermediate dual system of steel moment frame was chosen with int...