In the present study, influence of initial heat-treatment conditions on artificial aging behavior after conventional linear extrusion at room temperature was investigated for precipitation hardening a 6056 aluminum alloy. A solution-annealed condition systematically compared to naturally-aged and pre-aged conditions. Differential scanning calorimetry used analyzing sequence its dependence heat ...

Rejuvenators improve the performance of reclaimed asphalt mixtures but relatively little is known about their long-term aging characteristics. This study evaluated effect four different rejuvenators on characteristics 100% mixtures. Rheological tests extracted bitumen revealed that tall oil-based rejuvenator showed highest reduction and petroleum-based lowest in stiffness binder long term. At l...

Age-related hearing loss (AHL) is a common disorder associated with aging. In this study, we investigated the effect of the intake of heat-killed Lactococcus lactis subsp. cremoris H61 (strain H61) on AHL in C57BL/6J mice. Measurement of the auditory brainstem response (ABR) demonstrated that female mice at 9 months of age fed a diet containing 0.05% strain H61 for 6 months maintained a signifi...

EFFECTS OF HYPERTENSION AND AGING ON VASCULAR SMOOTH MUSCLE CELL CONTRIBUTION TO RECONSTITUTED AORTIC TISSUE STIFFNESS by Nancy Lisa Sehgel Aortic stiffness increases with hypertension and aging, and much of this increase has been thought to occur due to changes in the extracellular matrix. However, an increase in cell stiffness could also be important. To study the cellular contribution to aor...

We investigate the nonlinear rheological behavior of colloidal suspensions of Laponite, a synthetic clay, driven by steady homogeneous shear strain. We show that the external drive leads to drastic slowing down of the aging dynamics or even, in some cases, in rejuvenation of the system. Under shear, after a surprisingly long time, the spontaneous aging process observed at rest is suppressed. Th...

introduction: sandfish (holothuria scabra) is a marine species generally sold as a raw material that has been dried even though the meat contains steroid hormone with high economic value, which has the potential to become a source of safe natural steroid hormone. this study was aimed to look at the potency of sandfish as an anti-aging for menopausal women. sandfish could become a source of natu...

This study identified gene expression profiles that provided evidence for genomic mechanisms underlying the pathophysiology of aging lung. Aging lungs from C57BL/6 (B6) and DBA/2 (D2) mouse strains differ in physiology and morphometry. Lungs were harvested from B6 mice at 2, 18, and 26 mo and from D2 mice at 2 and 18 mo of age. Purified RNA was subjected to oligonucleotide microarray analyses, ...

Since Harman proposed the "free-radical theory of aging", oxidative stress is postulated to be a major causal factor of senescence. Accumulation of oxidative stress-induced oxidatively modified macromolecules including protein, DNA, and lipid, were found in tissues during the aging process. However, it is not necessarily clear which factor is more critical for an increase in endogenous reactive...

Sex differences in ageing rates and lifespan are common in nature, and an enduring puzzle for evolutionary biology. One possibility is that sex-specific mortality rates may result from recessive deleterious alleles in 'unguarded' heterogametic X or Z sex chromosomes (the unguarded X hypothesis). Empirical evidence for this is, however, limited. Here, we test a fundamental prediction of the ungu...

A quantitative investigation into the balancing and locomotor function, learning and memory of mice infected with an arthropod-borne virus is described. Mice can remain on a rod rotating in a horizontal plane about its long axis, and this natural ability can be assessed by counting the number of times they fall off. The mice improve their ability with experience and can retain the improved abil...