Introduction: Ghrelin and Orexin A exert inhibitory effects on gonadotropins secretion. Aromatase is a key enzyme in the steroidogenesis pathway which converts testosterone to the estradiol. Treatment of neonatal female rats with testosterone propionate (TP) alters gonadotropin secretion patterns in the adulthood. In the present study the effects of central injection of ghrelin or orexin A o...

Abstract Reproductive performance is central to profitability in beef cattle operations. Pathogenic stress can result from gram-negative bacteria release of the lipopolysaccharide (LPS) endotoxin which has potential accumulate follicular fluid and impair folliculogenesis steroidogenesis, leading reduced fertility. Elevated LPS concentrations observed acute clinical bacterial infections are reco...

BACKGROUND This study aimed to investigate the effect of polycystic ovary syndrome (PCOS) on the association of aromatase activity assessed by estradiol-to-testosterone ratio (E2/T) with body mass index (BMI) in women. METHODS This was a cohort study in five centers for reproductive medicine in China. Data were collected from July 2012 to December 2013. PCOS patients (n = 785) and non PCOS, h...

Sex hormones play an active role in inflammatory responses, with androgens being anti-inflammatory, whereas estrogens have both pro- and anti-inflammatory effects. In rheumatoid arthritis (RA) patients, low levels of androgens and high levels of estrone are found in the synovial fluid. Aromatase is the key enzyme for the conversion of androgens into estrogens. Proinflammatory cytokines stimulat...

Sex steroid hormones are major regulators of sexual characteristic among species. These hormones, however, are also produced in the brain. Steroidal hormone-mediated signalling via the corresponding hormone receptors can influence brain function at the cellular level and thus affect behaviour and higher brain functions. Altered steroid hormone signalling has been associated with psychiatric dis...

Epidemiological and experimental findings suggest that the development of gastric cancer (GC) is regulated by steroid hormones. In postmenopausal women and older men, the majority of steroid hormones are produced locally in peripheral tissue through the enzymatic conversion of steroid precursors. Therefore, using reverse transcription-quantitative polymerase chain reaction analysis, the mRNA ex...

In recent years, there has been increasing recognition of the importance of steroid aromatization in organs besides the steroidogenic ones. Estrogens formed from C-19 precursors in peripheral tissues can clearly contribute to the levels of estro gens in the circulation, while aromatization in target cells may be an important determinant of the concentration of estrogens to which a particular po...

Abstract: Aim: Breast cancer is one of the most common cancers among women, consistently elevated estrogen level in blood associated with persistently breast found many studies. The mechanisms carcinogenesis whereby involved conversion androgen to presence enzyme aromatase. Materials and Methods: Aromatase a (CYP19), cytochrome P450, which that synthesizes estrogen. expressed higher concentrati...

Background Estrogens biosynthesis in ejaculated spermatozoa is an autonomous process that may influence sperm functions. The purpose of this study was to evaluate the relationship between the expression of aromatase, sperm quality and seminal neutral α–glucosidase marker in semen of Tunisian infertile men. MaterialsAndMethods Fifty seven men were investigated: they were composed of two groups: ...

During obesity, excess body weight is not only associated with an increased risk of type 2-diabetes, but also several other pathological processes, such as infertility. Adipose tissue the largest endocrine organ that produces adipokines, including adiponectin. Adiponectin has been reported to control fertility through hypothalamic–pituitary–gonadal axis, and folliculogenesis in ovaries. In this...