Pulsatile drug delivery systems (PDDS) are gaining importance as they deliver a drug at specific time as per the pathophysiological need of the disease, resulting in improved therapeutic efficacy as well as compliance. Diseases wherein PDDS are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia. These deli...

We study e cient implementations of the push-relabel method for the maximum ow problem. The resulting codes are faster than the previous codes, and much faster on some problem families. The speedup is due to the combination of heuristics used in our implementation. We also exhibit a family of problems for which all known methods seem to have almost quadratic time growth rate. Andrew V. Goldberg...

During much of the 21st century, natural runoff in Colorado River basin has declined, while consumption remained relatively constant, leading to historically low reservoir storage. Between January 2000 and April 2023, amount water stored Lake Mead Powell, two largest reservoirs United States, declined by 33.5 million acre feet (41.3 billion cubic meters). As total basin-wide storage was suffici...

We derive a geometric criterion for the convexity of Powell-Sabin interpolants and present a multivariate generalization.