MISSION (ARM): QUANTATIVE IRON MINERALOGY AND OXIDATION STATES. C. Schröder, G. Klingelhöfer, R. V. Morris, A. S. Yen, F. Renz, and T. G. Graff, Biological and Environmental Sciences, University of Stirling, Stirling FK9 4LA, Scotland, UK, [email protected], Institute of Inorganic Chemistry and Analytical Chemistry, Johannes Gutenberg-University, Staudinger Weg 9, 55128 Mainz, Germ...

cis-3-Acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones were prepared through a Staudinger [2+2]-cyclocondensation between acetoxyketene and the appropriate epoxyimines in a highly diastereoselective way. Subsequent potassium carbonate-mediated acetate hydrolysis, followed by intramolecular ring closure through epoxide ring opening, afforded stereodefined 3-aryl-4-hydroxy-2-oxa-6-azabicyclo[3.2.0]he...

FROM JAROSITE AT MERIDIANI PLANUM TO GOETHITE AT GUSEV CRATER. G. Klingelhöfer, D.S. Rodionov , R.V. Morris, C. Schröder, P.A. de Souza, D.W. Ming, A.S. Yen, B. Bernhardt, F. Renz, I. Fleischer, T. Wdowiak, S.W. Squyres, and the Athena Science Team. Institut für Anorganische und Analytische Chemie, Johannes Gutenberg-Universität, Staudinger Weg 9, D-55128 Mainz, Germany, [email protected]...

The traditional Staudinger/aza-Wittig reaction represents one of the most powerful tools for imine formation. However, this multistep procedure, sacrificial phosphine has to be used, resulting in difficulties purification process and waste disposal at same time. Here, we report a redox-neutral azide–alcohol imination methodology enabled by base-metal nickel PN3 pincer catalyst. one-step, waste-...

A fast and efficient protocol for the synthesis of N,N'-disubstituted urea derivatives from alkyl halides and primary or secondary amines has been developed. The synthetic pathway combines nucleophilic substitutions and a Staudinger-aza-Wittig reaction in the presence of polymer-bound diphenylphosphine under 14 bar of CO2 pressure and has been performed in a one-pot two-step process. The protoc...

For more than two decades, the Center for Lifespan Psychology has promoted a perspective on behavioral development that seeks to integrate age periods, domains of functioning, timescales, and levels of analysis. In part through these efforts, lifespan psychology has evolved into a distinct conceptual approach within developmental psychology (e.g., Baltes, 1987; Baltes, Lindenberger, & Staudinge...

A novel method for radioisotope-free photoaffinity labeling was developed, in which a bifunctional ligand is connected to a target protein by activation of a photoreactive group, such as an aromatic azido or 3-trifluoromethyl-3H-diazirin-3-yl group, and identification of the ligated product is achieved by anchoring of a detectable tag through the Staudinger-Bertozzi reaction with an alkyl azido...

N-Myristoyl transferase-mediated labelling using a substrate modified with an azide or alkyne tag is described as an efficient and site-selective method for the introduction of a bioorthogonal tag at the N-terminus of a recombinant protein. The procedure may be performed in vitro, or in a single over-expression/tagging step in vivo in bacteria; tagged proteins may then be captured using Staudin...

thionyl chloride (or oxalyl chloride) has been used as an efficient and cheap acid activator for one-pot synthesis of β-lactams in good to excellent yields by reaction between imines and acids in the presence of triethylamine at room temperature.