نتایج جستجو برای: stat4
تعداد نتایج: 718 فیلتر نتایج به سال:
Mechanisms that initiate lupus nephritis and cause progression to end-stage renal disease remain poorly understood. In this study, we show that lupus-prone New Zealand Mixed 2410 mice that develop a severe glomerulosclerosis and rapidly progressive renal disease overexpress IL-4 in vivo. In these mice, STAT6 deficiency or anti-IL-4 Ab treatment decreases type 2 cytokine responses and ameliorate...
Regos nervas – baltosios smegenų medžiagos struktūra, kuri jungia smegenis su tinklaine ir atlieka regimosios informacijos perdavimo funkciją. Anatomiškai šią struktūrą galima suskirstyti į 4 segmentus: akinį, akiduobinį, kaukolės dėžėje esančią dalį kaulo kanale nervo dalį. Neretai regos veikiamas įvairių aplinkos bei genetinių veiksnių, kurie gali turėti įtakos uždegimo atsiradimui. Bene ger...
Sezary syndrome (SS) is the leukemic variant of CD4+ cutaneous T-cell lymphoma. Mogamulizumab an FDA-approved monoclonal antibody targeting surface CCR4 on SS cells. We’ve previously described highly expressed biomarker genes and altered cytokine gene expression that favors a Th2-immune phenotype. Here we evaluated mogamulizumab’s efficacy in reducing malignant T-cells, decreasing expression, m...
464 STAT4 deficiency exacerbates atherosclerosis by promoting mobilization of myeloid cells, polarization of M1 macrophages and formation of foam cells L. Xu1; S. Ding2; J. Yang1; X. Yang2; J. Ge1 Zhongshan Hospital, Fudan University, Cardiology Department, Shanghai, China People’s Republic of; Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China ...
We have reported that hepatitis B X-interacting protein (HBXIP) promotes the proliferation and migration of breast cancer cells. However, the underlying mechanism is poorly understood. In this study, we report that HBXIP works in the event through up-regulating S100A4. We observed that HBXIP expression was positively correlated to that of S100A4 in 87 clinical breast cancer tissue samples. Then...
BACKGROUND Though HLA-DP/DQ is regarded to associate with HBV susceptibility and HBV natural clearance, its role in hepatocellular carcinoma (HCC) development is obscure. And the role of STAT4 in HBV susceptibility and clearance as well as HCC development is still contentious. Therefore, we conducted this study, aiming to clarify these obscure relationships. METHODS We recruited 1312 Chinese ...
BACKGROUND Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q. METHODS We tested single-nucleotide polymorphisms (SNPs) in and around 13 candidate genes within the previously linked chromosome 2q region for association with rheumatoid arthritis. We then performed fine mapping of ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید