OBJECTIVE Moderate weight gain is usual after starting insulin therapy. The identification and quantification of factors associated with weight gain may help target strategies for avoidance of weight gain. RESEARCH DESIGN AND METHODS The noninterventional CREDIT (Cardiovascular Risk Evaluation in people with type 2 Diabetes on Insulin Therapy) study included data from people with type 2 diabe...

BACKGROUND Bodyweight-based dosing of tacrolimus (Tac) is considered standard care, even though the available evidence is thin. An increasing proportion of transplant recipients is overweight, prompting the question if the starting dose should always be based on bodyweight. METHODS For this analysis, data were used from a randomized-controlled trial in which patients received either a standar...

Workshop participants agreed that tests of basal cytotoxicity were sufficiently predictive for the rodent LD50 such that cytotoxicity tests could be used to predict a starting dose for an in vivo lethality assay (NIEHS, 2001). This section discusses how to proceed. Theoretically, any in vitro test capable of determining basal cytotoxicity could be used to determine the best estimate of a starti...

In this issue of the Journal, Ratain and his colleagues (/) revisit a number of issues that are of considerable importance to physicians who conduct early clinical trials of new anticancer agents and to the patients who participate in these trials. Because anticancer agents typically have a low therapeutic index, the initial dose level in phase I trials for most agents has been equivalent to Vi...

We usually perform animal studies to provide scientific data or to explain the mechanisms of traditional Korean medicines (TKM) based on their demonstrated efficacy in clinical application or as mentioned in old TKM literature. Similarly, we focus on toxic and safety aspects of TKM using preclinical models so as to promote them as effective over the counter (OTC) or ethical drugs. Often a presc...