Are medicines dangerous chemicals or life enhancing agents? The answer is ‘Both of those things, often at the same time, and worse in the wrong hands’. In this issue of the Annals, several authors address the problems besetting specialists who assess drug efficacy and safety. The last two articles describe activities (pharmacogenetics, and engineered drug delivery) which may produce unforeseen ...

This document describes an experiment with the purpose of developing a proof-of-concept for a prototype for a workflow component for GMT, the Generative Model Transformer Open Source effort. It discusses the challenges we met in trying to adhere to standards and the problems of using existing “wizards”. Despite this, generative development proved to be effective.

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 190 R I. DISABILITY AS AN ELIGIBILITY CRITERION: THE PROBLEM OF DEFINITION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 R A. Defining Disability as an Eligibility Criterion . . . . . . . . 195 R B. Refining the Definition: Significant Ch...

‎an  oriented perfect path double cover (oppdc) of a‎ ‎graph $g$ is a collection of directed paths in the symmetric‎ ‎orientation $g_s$ of‎ ‎$g$ such that‎ ‎each arc‎ ‎of $g_s$ lies in exactly one of the paths and each‎ ‎vertex of $g$ appears just once as a beginning and just once as an‎ ‎end of a path‎. ‎maxov{'a} and ne{v{s}}et{v{r}}il (discrete‎ ‎math‎. ‎276 (2004) 287-294) conjectured that ...

Abstract Should we use the same standard of proof to adjudicate guilt for murder and petty theft? Why not tailor crime? These relatively neglected questions cut heart central issues in philosophy law. This paper scrutinises whether ought all criminal cases, contrast with a flexible approach that uses different standards crimes. I reject consequentialist arguments radically proof, instead defend...

we give a new proof of the well known wedderburn's little theorem (1905) that a finite‎ ‎division ring is commutative‎. ‎we apply the concept of frobenius kernel in frobenius representation theorem in finite group‎ ‎theory to build a proof‎.

this paper presents a proof of stirling's formula using haar wavelets and some properties of hilbert space, such as parseval's identity. the present paper shows a connection between haar wavelets and certain sequences.

background: infant mortality rate is reported 3.18 in 1000 births in iran. international organizations such as world health organization (who) and united nations children's fund (unicef) consider applicable standards essential for providing effective health services in hospitals and health centers. therefore, it is essential to create national care standards for neonatal intensive care units (n...