Required) This study intends to utilize Evidence-Based Medicine (EBM) to support liver organ allocation policy making. The current liver organ allocation policy---the MELD scoring system suffers from several limitations in evaluating patients’ post-transplant survival. This study intends to develop a more cost effective policy for liver organ allocation which includes both recipients’ factors a...

The incidence or diagnostic rate of sclerosing cholangitis is increasing. Because of the lack of effective medical or surgical therapy for patients with end-stage liver disease and sclerosing cholangitis, results with orthotopic liver transplantation were examined. The results of 55 consecutive liver replacements for this disease were reviewed. The 1- and 2-year actuarial survival rates are 71%...

BACKGROUND & AIM The association of circulating sphingosine-1-phosphate (S1P), a bioactive lipid involved in various cellular processes, and related metabolites such as sphinganine-1-phosphate (SA1P) and sphingosine (SPH) with mortality in patients with end-stage liver disease is investigated in the presented study. S1P as a bioactive lipid mediator, is involved in several cellular processes, h...

L ung transplantation is an acceptable therapy with which to palliate patients with a variety of endstage lung diseases, but there is a severe shortage of suitable donor lungs to meet the demand (Fig 1), which hinders broad application. In the last 5 years, approximately 2,500 potential lung recipients have died while on the UNOS lung transplant waiting list.1 Because of the shortage of lungs f...

Cirrhosis with end stage liver disease is a leading cause of non-communicable related deaths in Sri Lanka. Liver transplantation remains the only curative treatment for such patients. Multi-organ dysfunction characteristic disease, surgical and anaesthetic factors, quality graft, coagulopathy haemodynamic instability, all lead to complexity perioperative care transplant. Aggressive management f...