OBJECTIVES Treatment with pamidronate improves the clinical course in children with osteogenesis imperfecta (OI), but theoretically might affect longitudinal growth. In this study we analyzed growth during cyclical intravenous pamidronate treatment in children and adolescents (age.04-15.6 years at baseline) with moderate to severe forms of OI types I, III, and IV. METHODS The effect of 1 year...

We present several variations of a model of gain control in the retina of the toad Bufo marinus, and use them to fit the threshold-vs-intensity data of an actual toad ganglion cell [Donner et al. (1990). Journal of General Physiology, 95, 733-753]. Our models are based on a proposal by Donner et al. that the gain (neural spike per photon ratio) of toad ganglion cells is set by a sequence of two...

Colorectal cancer (CRC) is a heterogeneous disease with a high mortality rate and is still lacking an effective treatment. Our goal is to develop a robust prognosis model for predicting the prognosis in CRC patients. In this study, 871 stage II and III CRC samples were collected from six gene expression profilings. ColoFinder was developed using a 9-gene signature based Random Survival Forest (...

We present a broadband optical parametric amplifier design using tapered gain and tandem chirped quasi-phase-matching gratings to obtain flat gain and group-delay spectra suitable for applications such as ultrashort-pulse amplification and fiber-optic communication systems. Although a tapered-gain amplifier consisting of a single chirped grating can provide constant gain over a wide frequency r...

This application note outlines the use of the ispPAC®10 in differential circuits for bridge networks. The ispPAC10 architecture is well suited for instrumentation measurement since both inputs and outputs are differential. In-System Programmability (ISPTM) and programmable gain control allow the user to reconfigure the device characteristics after it is soldered onto a circuit board. System off...

Growing interest in the electrical properties of living organisms has required the development of amplifiers sufficiently sensitive and stable to record the minute changes in potential encountered. Such amplifiers must be of high gain, with differential input (so that several amplifiers may be used simultaneously on one specimen), freedom from voltage drift, and should be direct coupled through...

Background MCL1 copy number variations have been reported to be associated with cancer prognosis in several cancers. However, the role of MCL1 gain has not yet been determined in esophageal squamous cell carcinomas (ESCC). Methods Fluorescence in situ hybridization (FISH) for MCL1 was performed on 262 ESCC samples using tissue microarray (TMA). Results The median age of ESCC patients was 62...

A new current mirror with accurate mirror gain for low β transistors is presented. The new current mirror employs a cascoded output stage to provide high output impedance. High mirror gain accuracy is achieved by using a split-collector transistor to compensate for base currents of the source-coupled transistor pair. The split factor is dependent on the desired mirror gain and the nominal β value.