Objective(s): Currently, the development of nanoparticles for the stabilization and targeted delivery of cardiac drugs has gained significance. The present study aimed to develop nontoxic nanoparticles based on chitosan-hyaluronic acid (HA), encapsulate dinitrosyl iron complexes (DNICs, donors NO) into the nanoparticles to increase the stability and effectiveness of their action, and assess the...

Traditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in presented paper, complexation of Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using UV/Vis spectroscopy. Formation host: guest registered: Qu...

In this review, we focus on cyclic voltammetry as a reliable electrochemical technique to study mechanisms, kinetics and thermodynamics of various types of drug-drug interactions. While we present and discuss six theoretical models relevant to analyze drug-drug (or drug-DNA) interactions, we also give hints about recent experimental achievements in this field. In addition, we provide the reader...

A model independent analysis is made using the LEP and SLD data on Z decays available at the end of 1996. The effective weak coupling constants of leptons, c quarks and b quarks are extracted. Except for the right-handed b quark coupling, they all agree with the predictions of the Standard Electroweak Model for mt = 180 GeV and mH = 100 GeV. The right-handed b quark coupling is found to be 42% ...

Differential scanning calorimetric experiments show that addition of Al(III) to conalbumin increases its denaturation temperature by 5 degrees, from 60 to 68 degrees. Only one Al(III) bound per conalbumin molecule produces this change in heat stability; additional bound Al(III) does not affect the heat stability. Since Al(III) displaces both Cu(II) bound at the metal binding sites of conalbumin...

The equilibrium constants K1, Ka and β1 of 25 copper(II) complexes with di(N = 15), tri(N = 5), tetra(N = 2), and pentapeptides (N = 3) were estimated by using linear models based on the valence connectivity index of the 3 order (χ). For the stability constant K1 two kinds of models were developed: bivariate models, which divide a molecule into Nand C-terminal segments, and multivariate models,...

a computational study of the electronic structure and stability of complexes formed between zeolite y and boric acid was carried out at the hf and b3lyp levels using 6-31g* basis set. five structures located as local minimum in pes of complex (structures d, e, f, g, and h). the most stable structure is formed due to hydrogen bonding between two hydroxyl of boric acid and both oxygen of ...