Introduction The receptor tyrosine kinase Axl is described as a driver for migration and metastasis well resistance against molecular targeting agents radio- chemotherapy (RCT) in various tumor entities including head neck squamous cell carcinoma (HNSCC). For the latter, clinical data describing impact of its ligand Gas6 on patient outcome are sparse.

Management of patients with metastatic squamous cell skin cancer, refractory to initial therapy with standard chemotherapy and radiation protocols, remains difficult with poor overall prognosis and limited therapeutic options. Recently, promising response rates with nivolumab, a programmed death receptor-1-blocking antibody, in squamous cancer of the head and neck have been demonstrated. Consid...

Imaging head and neck cancer is crucial for treatment decisions and follow-up of patients. The choice of the appropriate imaging modality for staging and re-staging head and neck cancer can be troublesome. This review highlights the important questions of imaging from a clinician's perspective. The recommendations focus on mucosal squamous cell carcinoma of the head and neck since this is the m...

OBJECTIVE To determine if the use of autologous blood ameliorates the increased risk for cancer recurrence that has been associated with perioperative blood transfusion. DESIGN Retrospective medical record review. SETTING Tertiary care hospital. PATIENTS One hundred sixty-five consecutive patients with stages II to IV squamous cell carcinoma of the head and neck treated surgically at a un...

The semaphorins belong to a family of proteins originally shown to be important in axon migration and proper central nervous system development. Recent evidence has demonstrated that semaphorins and their receptors are expressed in tissues outside of the nervous system and represent a widespread signaling system that is involved in regulation of motility in many different cell types. This revie...