The possibility that spreading depression (SD) of cortical activity, a phenomenon observed in all vertebrates, causes the aura of migraine remains an open question in spite of nearly half a century of investigation. SD is also thought to be associated with the progressive neuronal injury observed during cerebral ischaemia. Thus, the ability to detect and investigate SD in humans might prove cli...

HULL, C. D., AND A. VAN HARREVELD. Absence oj conduction of spreading de)wession through cortical region damaged by asphyxiation. Am. J. Physiol. 207(4) : 92 I-924. Ig6+-An area of cerebral cortex was asphyxiated for 30-35 min by application of a weight exerting a pressure on the tissue greater than the blood pressure. Three days later the asphyxiated region showed in most. experiments a marked...

We analyzed the metabolic response to cortical spreading depression that drastically increases local energy demand to restore ion homeostasis. During single and multiple cortical spreading depressions in the rat cortex, we simultaneously monitored extracellular levels of glucose and lactate using rapid sampling microdialysis and glucose influx using 18 F-fluorodeoxyglucose positron emission tom...

The year of 2014 is the birth centenary of Aristides Azevedo Pacheco Leão (1914-1993), and also marks seventy years of the publication of his discovery of the novel electrophysiological phenomenon, named by him "spreading depression" (SD), soon designated "Leão's wave" or "Leão's spreading depression". This was a remarkable scientific milestone, and the author must be celebrated for this achiev...