Over the last decade, a number of monoclonal antibodies and small molecule inhibitors emerged as potent therapeutic agents in the treatment of Her2/neu overexpressing breast cancer. Numerous patients, however, do not adequately respond to anti-epidermal growth factor receptor (EGFR)/Her2 receptor targeting. Receptor- and, in turn, growth-stimulating effects, which potentially hamper antiprolife...

OBJECTIVES to assess whether measures of cognitive and physical function can explain differences in observed and healthcare resource group (HRG) predicted length of stay for patients presenting with six target conditions at admission. DESIGN prospective observational study. SETTING three East Kent district general hospitals. PARTICIPANTS One thousand nine hundred and forty-two consecutive...

Traditional techniques to map vegetation communities are by aerial photography interpretation and intensive field sampling. Semi-automated methods, including pixel and object-based image classification, demonstrate potential to accurately map vegetation communities, however, there is a lack of comparative research. This study is a component of a broader research project that compares several te...

A Hemispherical Resonator Gyro (HRG) is the Coriolis Vibratory Gyro (CVG) that measures rotation angle or angular velocity using Coriolis force acting the vibrating mass. A HRG can be used as a rate gyro or integrating gyro without structural modification by simply changing the control scheme. In this paper, differential control algorithms are designed for a 2-piece HRG. To design a precision c...

One layer of global geographic database Reference3D® is an image mosaic (5m resolution) made exclusively from panchromatic SPOT5-HRS images. In order to improve Reference3D® production line, in particular SPOT5 HRS images mosaicking step, a new strategy of radiometric block adjustment of satellite images was developed, implemented and tested at French mapping agency IGN. By analogy with “geomet...

The lacking of 1:50000 topographic maps in western China is inconvenient to the national economic development. The rapid development of space technology, computer technology and information technology provides technological support for the remote sensing application. In addition, the enhancement of ability of obtaining hyper-resolution data provides data for feature extraction of ground objects...

BACKGROUND: Heregulin (HRG) expressing cells are markedly more sensitive to doxorubicin (DOXO). Cells genetically engineered to overexpress HRG are aggressive and have the ability to bypass the normal estrogen requirements for growth. These HRG expressing cells are antiestrogen independent in vitro and in vivo. It has been shown that HRG internalizes to the nucleus, its localization from the nu...

Heterogeneous trajectory forecasting is critical for intelligent transportation systems, but it challenging because of the difficulty modeling complex interaction relations among heterogeneous road agents as well their agent-environment constraints. In this work, we propose a risk and scene graph learning method agents, which consists Risk Graph (HRG) Hierarchical Scene (HSG) from aspects agent...