Over the last decade, a number of monoclonal antibodies and small molecule inhibitors emerged as potent therapeutic agents in the treatment of Her2/neu overexpressing breast cancer. Numerous patients, however, do not adequately respond to anti-epidermal growth factor receptor (EGFR)/Her2 receptor targeting. Receptor- and, in turn, growth-stimulating effects, which potentially hamper antiprolife...

OBJECTIVES to assess whether measures of cognitive and physical function can explain differences in observed and healthcare resource group (HRG) predicted length of stay for patients presenting with six target conditions at admission. DESIGN prospective observational study. SETTING three East Kent district general hospitals. PARTICIPANTS One thousand nine hundred and forty-two consecutive...

A Hemispherical Resonator Gyro (HRG) is the Coriolis Vibratory Gyro (CVG) that measures rotation angle or angular velocity using Coriolis force acting the vibrating mass. A HRG can be used as a rate gyro or integrating gyro without structural modification by simply changing the control scheme. In this paper, differential control algorithms are designed for a 2-piece HRG. To design a precision c...

BACKGROUND: Heregulin (HRG) expressing cells are markedly more sensitive to doxorubicin (DOXO). Cells genetically engineered to overexpress HRG are aggressive and have the ability to bypass the normal estrogen requirements for growth. These HRG expressing cells are antiestrogen independent in vitro and in vivo. It has been shown that HRG internalizes to the nucleus, its localization from the nu...

Heterogeneous trajectory forecasting is critical for intelligent transportation systems, but it challenging because of the difficulty modeling complex interaction relations among heterogeneous road agents as well their agent-environment constraints. In this work, we propose a risk and scene graph learning method agents, which consists Risk Graph (HRG) Hierarchical Scene (HSG) from aspects agent...

Hyperedge replacement grammar (HRG) is a formalism for generating and transforming graphs that has potential applications in natural language understanding and generation. A recognition algorithm due to Lautemann is known to be polynomial-time for graphs that are connected and of bounded degree. We present a more precise characterization of the algorithm’s complexity, an optimization analogous ...

Bolin, M. 2012. Pre-eclampsia – Possible to Predict?: A Biochemical and Epidemiological Study of Pre-eclampsia. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 835. 66 pp. Uppsala. ISBN 978-91-554-8523-8. Pre-eclampsia is a major cause of maternal and perinatal morbidity and mortality worldwide. A predictor of pre-eclampsia w...