OBJECTIVE To detect the adverse drug reactions (ADRs) through spontaneous reporting system in IGGMC&H, Nagpur and analyze them using World Health Organization (WHO) assessment scales. METHOD An observational, prospective study was conducted based on ADRs reported between 1st June '05 to 31st May '09 to the ADR reporting unit of the hospital. The ADRs reported by spontaneous reporting system w...

OBJECTIVE Adverse drug events (ADEs) are common and account for 770 000 injuries and deaths each year and drug interactions account for as much as 30% of these ADEs. Spontaneous reporting systems routinely collect ADEs from patients on complex combinations of medications and provide an opportunity to discover unexpected drug interactions. Unfortunately, current algorithms for such "signal detec...

We are reporting a rare case of spontaneous atraumatic mediastinal hematoma in a previously apparently healthy middle aged female who presented with acute onset dysphagia, increasing neck swelling and spontaneous neck and chest bruising. Plain chest radiograph showed widening of the mediastinum. Contrast CT scan of neck and chest revealed a soft tissue swelling in retropharyngeal space causing ...

Wunderlich Syndrome is a rare condition in which spontaneous renal haemorrhage occurs into the subcapsular and perirenal spaces in absence of trauma. It can present as a life threatening situation with profound shock which demands urgent attention. Though angiomyolipoma of the kidney is the most common neoplasm associated with spontaneous renal haemorrhage, varied presentation and lack of suspi...

Adverse reactions are the recognized hazards of drug therapy and they can occur with any class of drugs and many studies revealed that the incidence is more in case of antibiotics. The main aim of this study was to detect and analyze Adverse Drug Reactions of antibiotics in inpatients of a tertiary care hospital. A prospective spontaneous reporting study by active and passive methods was carrie...

Post-marketing detection and surveillance of potential safety hazards are crucial tasks in pharmacovigilance. To uncover such safety risks, a wide set of techniques has been developed for spontaneous reporting data and, more recently, for longitudinal data. This paper gives a broad overview of the signal detection process and introduces some types of data sources typically used. The most common...

We are reporting a case of a young female, who presented to emergency room with sudden increase in thyroid swelling, high fever and acute respiratory distress. Clinical diagnosis of spontaneous infection of thyroid cyst was made. Operative finding was infection of thyroid cyst with gas formation. Systemic antibiotics and operative intervention by subtotal thyroidectomy led to recovery of the pa...