Drug delivery systems are promising pharmaceutical formulations used to improve the therapeutic index of drugs. In this study, we developed a liposomal formulation of furazolidone that targets Leishmania (Leishmania) chagasi amastigotes in a hamster model. Using laser scanning confocal microscopy, it was demonstrated that the liposomal drug co-localised with L. (L.) chagasi amastigotes within m...

MPP can be effective in the treatment of E. coli O101-induced diarrhea in mice. MPP can improve the weight loss caused by diarrhea, increase spleen and thymus indices, and reduce the diarrhea index. MPP can reduce the number of WBC, regulate the level of cytokines, and regulate the intestinal microbial flora. These data suggest that MPP is a promising candidate for treatment of E. coli-induced ...

Erythropoietin (EPO) is a glycoprotein hormone that regulates the proliferation and differentiation of erythroid progenitor cells in mammals. Although EPO has been identified in fish, the specific function and effects of hypoxia have not been investigated previously. In this study, we have demonstrated a relationship between increases in renal EPO levels and decreases in spleen EPO levels and s...

In the present study, the immunostimulatory activity of verbascose from mung beans (Phaseolus aureus) was evaluated by using in vitro cell models and in vivo animal models. The results of in vitro experiments showed that verbascose could enhance the ability of devouring neutral red of peritoneal macrophages and promote the release of nitric oxide and immune reactive molecules such as interleuki...

We report the case of a patient with acute exacerbation of chronic pancreatitis and he suffered an atraumatic splenic rupture. Splenic rupture not associated with trauma is a rare entity that can occurs in normal spleen (spontaneous) or damaged spleen (pathological). This entity may be associated with local inflammatory processes, such as pancreatitis. Ultrasound is a non-invasive technique whi...

BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune complex concentration were significantly reduced, and the morphology of the soleus muscle was restored in mice with sciatic nerve injury. These effects of Brazil were dose-dependent. O...

Introduction: Phasianidae is a non-migratory group of birds belonged to partridges family. One of the well-known species of partridge is Alectoris chukar, which is a medium-sized bird, larger than quails and smaller than pheasants. They are native to Asia, Africa, Europe and the Middle East and belong to the category of gallinaceous birds. Understanding the physiology and immunology of the lymp...

Pharmacognosy Research,2022,14,4,483-491.DOI:10.5530/pres.14.4.70Published:October 2022Type:Original ArticleAuthors:Ami Thakkar, Nirav Bhatia, and Gaurav Doshi Author(s) affiliations:Ami Thakkar1, Bhatia2, Doshi2,* 1Department of Pharmaceutical Analysis, Shobhaben Pratapbhai Patel School Pharmacy Technology Management, Vile Parle, Mumbai, Maharashtra, INDIA. 2Department Pharmacology, SVKM’s Dr....