Orientation of the cell division axis is essential for the correct development and maintenance of tissue morphology, both for symmetric cell divisions and for the asymmetric distribution of fate determinants during, for example, stem cell divisions. Oriented cell division depends on the positioning of the mitotic spindle relative to an axis of polarity. Recent studies have illuminated an expand...

Correct spindle alignment requires a cell to detect and interpret its global geometry and to communicate this information to the mitotic spindle. In the fission yeast, Schizosaccharomyces pombe, the mitotic spindle is aligned with the longitudinal axis of the rod-shaped cell. Here, using wild-type and cell-shape mutants we investigate the mechanism of initial spindle alignment and show that att...

Abstract Background Hemangioendothelioma is a rare vascular tumor of the head and neck region characterized by proliferation endothelial cells with epithelioid morphology. This an indolent known to appear during adult life, potential for recurrence, but unlikely metastasize. Although reports endotheliomas affecting soft tissues, skin, viscera, bone, or lymph nodes have been reported, very few c...

The orientation of the mitotic spindle plays a key role in determining whether a polarized cell will divide symmetrically or asymmetrically. In most cell types, cytoplasmic dynein plays a critical role in spindle orientation. However, how dynein directs opposite spindle poles toward distinct and predetermined cell ends is poorly understood. Here, we show that dynein distributes preferentially t...

The mitotic spindle is a complex and dynamic structure. Although much has been learned about how spindles assemble and mediate chromosome segregation, how spindles rapidly and irreversibly disassemble during telophase is less clear. We used synthetic lethal screens in budding yeast to identify mutants defective in spindle disassembly. Real-time, live cell imaging analysis of spindle disassembly...

概 要 心臓 に原発 する悪 性腫瘍は稀 なもの で,今 までのほ とん ど全てが心筋 よ りの肉腫 と心包上皮 か らの上 皮腫 であ る.こ れ ら腫瘍はJonasに よれ ば,現 在 までに全世 界に181例 が報 告されてい る.こ の うちhemangioendotheliomaは さ らに稀で,20例 には 達 しない.本 腫 瘍はRedtenb"cher(18892 に よ,;初 めて報 告 され,McNalley(1962)に よる纏が最 も新 しい もので ある.わ た く しは 最近その1 例 を経験 したので,そ の 臨床所 見お よび病 理解剖所見 を報 告す る.症 例41才,男.主 訴:胸 部 圧 迫感,体 動 時の動悸 と息 切れ.現 病 歴:昭 和37年12月 初 旬感冒様症状 発 現,発 熱37.5°C,.近 医の 治 療 に よ り一 旦軽快 して...

The cytoskeleton is responsible for major internal organization and re-organization within the cell, all without a manager to direct changes. This especially case during mitosis or meiosis, where microtubules form spindle cell division. machinery used segregate genetic material Toward creating self-organized spindles in vitro, we recently developed technique reconstitute into spindle-like assem...