The effects of pain stimulant and transcutaneous electrical nerve stimulation (TENS) on changes in substance P (SP) levels were investigated in the dorsal root ganglion (DRG) and dorsal horn of the spinal cord of Sprague-Dawley rats. The rats were divided into three groups: control, formalin stimulation and formalin+TENS. In all rats, the right sciatic nerve was attached to a hook electrode for...

Electrical spinal neuromodulation in the form of spinal cord stimulation is currently used for treating chronic painful conditions such as complex regional pain syndrome, diabetic neuropathy, postherpetic neuralgia, peripheral ischemia, low back pain, and other conditions refractory to more conservative treatments. To date, there are very few published reports documenting the use of spinal cord...

Injury to the brain or spinal cord usually preserves some corticospinal (CS) connections. These residual circuits sprout spontaneously and in response to activity-based treatments. We hypothesized that augmenting activity in spared CS circuits would restore the skilled motor control lost after injury and augment outgrowth of CS terminations in the spinal cord. After selective injury of one half...

Neuromodulation techniques modify the activity of the central or peripheral nervous system. Spinal cord stimulation is a reversible and minimally invasive treatment whose efficacy and cost effectiveness are recognized for the treatment of chronic neuropathic pain or ischemic pain. Spinal cord stimulation is not the option of last resort and should be considered among other options before prescr...

CRD summary The aim was to assess the cost-effectiveness of spinal cord stimulation compared with conventional medical management or reoperation, for patients with failed back surgery syndrome. The authors concluded that spinal cord stimulation was a cost-effective addition to conventional medical management and alternative to reoperation, for these patients. The methods and the reporting of th...

We present a patient with intractable neuropathic pain because of radiation-induced transverse myelitis unresponsive to medical treatment. After a successful trial of spinal cord stimulation, a permanent stimulator was implanted. Improvement was noted in verbal pain score, medication usage and function. Spinal cord stimulation may offer a therapeutic option for patients with neuropathic pain re...

Brain-computer interfaces (BCIs) are an emerging strategy for spinal cord injury (SCI) intervention that may be used to reanimate paralyzed limbs. This approach requires decoding movement intention from the brain control movement-evoking stimulation. Common methods use spike-sorting and require frequent calibration high computational complexity. Furthermore, most applications of closed-loop sti...

acute paraplegia is a rare but catastrophic complication of surgeries performed on aorta and corrective operations of vertebral column. trauma to spinal cord after spinal anesthesia and ischemia of spinal cord also may lead to acute paraplegia. acute paraplegia as a complication of general anesthesia in surgeries performed on sites other than aorta and vertebral column is very rare. here we pre...

The management of urinary tract dysfunction is crucial for the health and well-being of people with spinal cord injury. Devices, specifically catheters, play an important role in the daily regime of bladder management for most people with spinal cord injury. However, the high incidence of complications associated with the use of catheters, and the fact that the spinal segments involved in lower...

abstract   objective: to evaluate and review our experience with pediatric spinal injuries and factors affecting outcome, the authors conducted a retrospective clinical study of 43 cases (32 boys, 11 girls) of pediatric spine injuries treated during four years (january 1999 to december 2003).   methods: forty-three children with spinal injuries were studied retrospectively over four years and w...