A major solar particle event (SPE) may place astronauts at significant risk for the acute radiation syndrome (ARS), which may be exacerbated when combined with other space flight stressors, such that the mission or crew health may be compromised. The National Space Biomedical Research Institute (NSBRI) Center of Acute Radiation Research (CARR) is focused on the assessment of risks of adverse bi...

A 73-year-old male in whom diabetes mellitus and benign prostatic hypertrophy had been diagnosed was hospitalized with a urinary tract infection (UTI) showing urinary retention and a high grade fever. His symptoms worsened although several antibiotics were administered after admission. A chest radiograph shows multiple nodular lesions and cavity formations in both lung fields. Arterial blood ga...

methods coupled to isotope dilution–high-performance liquid chromatography–tandem mass spectrometry for measuring four isoflavones (daidzein, genistein, equol, and O-desmethylangolensin) and two lignans (enterolactone and enterodiol) in urine are developed. The SPE recoveries for the online SPE method are excellent for most analytes (83–94%) and somewhat lower for enterolactone (61%). The recov...

Manufacturers are required to supply more services in addition to just material products to customers recently. A new methodology is necessary to create value by combining services and products in this context. To serve this need, we propose a new engineering discipline called Service/Product Engineering (SPE). SPE differs from traditional, primitive engineering and concurrent engineering in th...

In re ent years Arvind's Group at MIT has shown the usefulness of term rewriting theory for the spe i ation of pro essor ar hite tures. In their approa h pro essors spe i ed by term rewriting systems are translated into a standard hardware des ription language for simulation purposes. In this work we present our urrent investigation on the use of Rewriting-Logi , whi h is a more powerful theore...

The Toll receptor was originally identified as an indispensable molecule for Drosophila embryonic development and subsequently as an essential component of innate immunity from insects to humans. Although in Drosophila the Easter protease processes the pro-Spätzle protein to generate the Toll ligand during development, the identification of the protease responsible for pro-Spätzle processing du...

Shrinking budgets and increased fiscal accountability mean that management needs a sound financial justification before committing funds to software process improvements such as Software Performance Engineering (SPE). Preparing a business case for SPE can demonstrate that the commitment is financially worthwhile and win support for an SPE initiative. This paper presents an introduction to the u...

The M protein and streptococcus pyrogenic exotoxin (SPE A) are important virulence factors in group A streptococci (GAS) infections. The emm types of GAS strains isolated from patients with sepsis were determined by sequencing the 5' N-terminus of the emm gene, encoding the M protein, and clonality analysis using pulsed-field gel electrophoresis. The presence of speA and production of SPE A wer...

Serum protein electrophoresis (SPE) is the hub of laboratory testing for monoclonal gammopathies and is a component of almost all diagnostic panels (1–3 ). The sensitivity of SPE as a screening test, however, is dependent on how SPE abnormalities are defined (4 ). Discrete, quantifiable electrophoretic bands (M-spikes) are almost always monoclonal proteins. Subtle abnormalities such as fuzzy ba...