Breast cancer is considered the most commonly diagnosed tumors. Biomarkers used for diagnosis and treatment of breast are: tissue biomarkers (PR, ER, HER2, Ki-67) serum (CA15-3, CA125, CA27.29, CEA, cytokeratins). ECD metalloproteinases leptin are emerging promising cancer. There a growing need personalized diagnostics based on tumor genome characterization, relying liquid biopsy containing com...

Progranulin (GRN) mutations causing haploinsufficiency are a major cause of frontotemporal lobar degeneration (FTLD-TDP). Recent discoveries demonstrating sortilin (SORT1) is a neuronal receptor for PGRN endocytosis and a determinant of plasma PGRN levels portend the development of enhancers targeting the SORT1-PGRN axis. We demonstrate the preclinical efficacy of several approaches through whi...

Sonic Hedgehog (Shh) is a secreted morphogen that is an essential regulator of patterning and growth. The Shh full-length protein undergoes autocleavage in the endoplasmic reticulum to generate the biologically active N-terminal fragment (ShhN), which is destined for secretion. We identified sortilin (Sort1), a member of the VPS10P-domain receptor family, as a new Shh trafficking receptor. We d...