Neuronal nitric oxide synthase (nNOS) has been reported to be up-regulated in the hypothalamic supraoptic nucleus (SON) during dehydration which in turn could increase nitric oxide (NO) production and consequently affect arginine vasopressin (AVP) secretion. The anteroventral third ventricle (AV3V) region has strong afferent connections with the SON. Herein we describe our analysis of the effec...

Recent advances in neuronal culturing techniques have supplied a new set of tools for studying neural tissue, providing effective means to study molecular aspects of regulatory elements in the supraoptic nucleus of the hypothalamus (SON). To combine molecular biology techniques with electrophysiological recording, we modified an organotypic culture protocol to permit transfection and whole cell...

Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in pati...

OF THE DISSERTATION Sins of the Father: An Investigation into Judgments and Processes Involved in Within-family Tainting by Stephanie Allison Peak Doctor of Philosophy in Psychological and Brain Sciences Washington University in St. Louis, 2017 Professor Alan J. Lambert, Chairperson The present research focused on a real-world event (i.e., the 2015 Paris terrorist attacks) as a basis for gainin...

Nesfatin-1, a newly discovered satiety molecule, is located in the hypothalamic nuclei, including the paraventricular nucleus (PVN) and supraoptic nucleus (SON). In this study, fine localization and regulation of nesfatin-1 neurons in the PVN and SON were investigated by immunohistochemistry of neuropeptides and c-Fos. In the PVN, 24% of nesfatin-1 neurons overlapped with oxytocin, 18% with vas...

The supraoptic nucleus (SON) of the hypothalamus is an important integrative brain structure that coordinates responses to perturbations in water balance and regulates maternal physiology through the release of the neuropeptide hormones vasopressin and oxytocin into the circulation. Both dehydration and lactation evoke a dramatic morphological remodeling of the SON, a process known as function-...

georges bernanos figure parmi les écrivains les plus importants du xxème siècle qui est récipiendaire du grand prix du roman de l'académie française pour son journal d'un curé de campagne en 1936. le journal relate l’histoire d’un curé de campagne qui ne réussit pas à établir le contact avec les paysans dont il a la charge. il est accusé d'avoir provoqué la mort de la comtesse qui s'est enfermé...

It’s a Boy! Women and Non-Monetary Benefits from a Son in India Son preference is widespread in a number of developing countries. Anecdotal evidence suggests that women may contribute to the persistence of this phenomenon because they derive substantial long-run non-monetary benefits from giving birth to a son in the form of an improvement in their intra-household position. This paper tests thi...

Topographic maps are salient features of neuronal organization in sensory systems. Inhibitory components of neuronal circuitry are often embedded within this organization, making them difficult to isolate experimentally. The auditory system provides opportunities to study the topographic organization of inhibitory long-range projection nuclei, such as the superior olivary nucleus (SON). We anal...

G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors in the mammalian genome. They are activated by a multitude of different ligands that elicit rapid intracellular responses to regulate cell function. Unsurprisingly, a large proportion of therapeutic agents target these receptors. The paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamu...