Case: A 51-year-old man presented with lymphadenopathy and increasing fatigue. He had been diagnosed chronic myeloid leukaemia (CML) seven months earlier a suboptimal response to first line nilotinib, failing achieve MR1 BCR-ABL1/ABL persistently >10% (IS). repeat bone marrow examination showed 90% blasts, consistent CML in blast phase (CML-BP). The blasts monoblastic morphology immunophenotype...

An attempt was made to identify the chromosomes from different species genomes in BC₂ progenies of Erianthus procerus x Saccharum officinarum through multi-color GISH (MCGISH). The population derived cross between a BC1 hybrid (GU 12-14) and commercial variety, Co 16018. BC2 were studied for their somatic chromosome number two cytotypes observed, i.e., 2n=92 (2) 2n=96 (5). revealed that majorit...

Background Women with Turner syndrome (TS) (45,X and related karyotypes) have an increased prevalence of conditions such as diabetes mellitus, obesity, hypothyroidism, autoimmunity, hypertension, congenital cardiovascular anomalies (CCA). Whilst the risk developing these co-morbidities may be partly to haploinsufficiency key genes on X chromosome, other mechanisms involved. Improving our unders...

The causes of schizophrenia and bipolar human psychiatric disorders are unknown. A novel somatic cell genetic model postulated nonrandom segregation of "Watson" vs. "Crick" DNA chains of both copies of a chromosome to specific daughter cells. Such an oriented asymmetric cell division causes development of healthy, functionally nonequivalent brain hemispheres. Genetic translocations of the chrom...

We have identified and characterized 40 DNA probes detecting restriction fragment length polymorphism (RFLP) on human chromosome 4. Single copy human clones were isolated from a bacteriophage library enriched for chromosome 4 sequences. Each clone was hybridized to somatic cell hybrid DNAs for verification of its species and chromosomal origin and for regional localization. Sequences specific f...

The human interferon gamma receptor has previously been assigned to chromosome 6. Chromosome 6 also encodes HLA, the human class I major histocompatibility antigens. However, the presence of chromosome 6 in hamster-human hybrids is by itself insufficient to confer sensitivity to human immune interferon as measured by the induction of human HLA. Human chromosome 21 was found to be the second chr...

Class I: Chromosome increase occurs in the first generation through the union of gametes one or both of which are unreduced. Can occur following selfor crosspollination. Class II: Chromosome doubling occurs in offspring of a hybrid with meiotic disturbances leading to unreduced gametes. It’s a second generation phenomenon: F2, BC1 or F1 crossed to a third parent. Class III: Chromosomal doubling...