Despite the fact that gross chromosome changes in malignant tumors were first described in human solid tumors more than 100 years ago by Arnold [1], cytogenetic analysis of solid tumors is still in its infancy compared to studies of leukemic cells [for review see 2, 3]. Advances in solid tumor cytogenetics have been and still are at the mercy of methodology, with the most limiting factors being...

The limited penetration of paclitaxel into solid tumors may limit its therapeutic efficacy. We recently showed a correlation between an increase in interstitial space and an enhancement of drug delivery in solid tumors. The present study evaluated whether this observation can be used to develop a treatment strategy, where an apoptosis-inducing pretreatment with paclitaxel is used to enhance its...