The nano drug delivery system has emerged as a novel therapeutic approach for improved efficacy of the existing molecules. Polymeric nanoparticles, lipid based nanoparticles such solid (SLNs), nanostructured carriers, conjugates, ethosomes, liposomes, and self-emulsifying systems are few carriers used delivery. Among SLNs promising in terms biocompatible carrier enhancing bioavailability, contr...

Recently, therapeutic proteins have been used to combat life-threatening diseases. To date, oral routes developed deliver proteins. Since the proteolytic degradation in upper gastrointestinal tract frequently occurs, we need a formulation and strategy protect protein colon. In this research, solid lipid nanoparticles (SLNs) were prepared eight formulae for colon-targeted delivery with various g...

This paper highlights the importance of lipid-based colloidal carriers and their pharmaceutical implications in the delivery of peptides and proteins for oral and parenteral administration. There are several examples of biomacromolecules used nowadays in the therapeutics, which are promising candidates to be delivered by means of liposomes and lipid nanoparticles, such as solid lipid nanopartic...

In spite of recent advances in targeted tumor therapy, systemic chemotherapy with cytotoxic agents remains a vital cancer treatment modality. Gemcitabine is a nucleoside analog commonly used in the treatment of various solid tumors, but an oral gemcitabine dosage form remain unavailable. Previously, we developed the 4-(N)-stearoyl gemcitabine solid lipid nanoparticles (GemC18-SLNs) by incorpora...

Solid lipid nanoparticles (SLNs) are the effective lipid based colloidal carriers which were introduced as an alternative to the conventional carriers such as microemulsions, liposomes, microparticles and nanoparticles based on synthetic polymers or natural macromolecules. Typically they enhance the oral bioavailability of the low aqueous soluble drugs due to their potential to enhance gastroin...

INTRODUCTION The field of Novel Drug Delivery System is emerging at an exponential rate with the deep understanding gained in diversified fields of Biotechnology, Biomedical Engineering and Nanotechnology. Many of the recent formulation approaches utilize Nanotechnology that is the preparation of Nanosized structures containing the API. Nanotechnology, as defined by the National Nanotechnology ...

A series of aliphatic esters of the NSAID naproxen (NAP) were synthesised and encapsulated in solid lipid nanoparticles (SLN) to evaluate the influence of lipophilicity on drug loading and release, as well as physicochemical properties and stability of SLN. The lipophilicity of esters mainly showed to influence their affinity for the solid lipid matrix, modifying the drug release profile compar...

BACKGROUND As part of a project designing nanoparticles for the treatment of Alzheimer's disease, we have synthesized and characterized a small library of nanoparticles binding with high affinity to the β-amyloid peptide and showing features of biocompatibility in vitro, which are important properties for administration in vivo. In this study, we focused on biocompatibility issues, evaluating p...