Iodine is a critical element involved in thyroid hormone synthesis. Its efflux into the follicular lumen is thought to occur, in part, through pendrin at the apical membrane of thyrocytes. This study attempted to investigate whether iodide administration affects SLC26A4 mRNA expression in rat thyroid and in PCCl3 cells. Rats and cells were treated or not with NaI from 30 min up to 48 h. One gro...

Scott, Reavis, Saunders, and White (1) have proposed a method of evaluating thyroidal function which depends upon knowledge of the distribution of iodide between erythrocytes and plasma in the blood. Their proposal is based upon the statement that the ratio C&/Cl, = 1,/I, = 0.5, where the subscripts c and p refer to cells and plasma, respectively. Earlier, Rall, Power, and Albert (2) had indica...

When iodides are administered in ordinary doses excretion takes place rapidly. Heavy doses can usually be administered before toxic symptoms develop. The same is true to an even greater extent of bromides. The bromide ion appears to be capable of replacing the chloride ion to a Considerable degree in the body fluid of mammals without the production of distinct toxic symptoms. Thus Frey (1910--1...

Loss-of-function mutations of the PAX8 gene are considered to mainly cause congenital hypothyroidism (CH) due to thyroid hypoplasia. However, some patients with PAX8 mutation have demonstrated a normal-sized thyroid gland. Here we report a CH patient caused by a PAX8 mutation, which manifested as iodide transport defect (ITD). Hypothyroidism was detected by neonatal screening and L-thyroxine re...

BACKGROUND/AIMS Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified. A calcium-activated pathway of iodide efflux has long been recognized, but its molecular identity unknown. Anoctamin 1 (ANO1) is a calcium-activated chloride channel (CaCC), and this stu...

Arsenic is classified as a carcinogen for humans, but as a possible genotoxic agent. Thus, taking into account the controversial data about how arsenic compounds are able to induce genetic damage, we investigated the possible genotoxic activity of different arsenic compounds in the TK6 human lymphoblastoid cell line using the alkaline Comet assay. Eight different inorganic and organic arsenical...

A direct and an efficient conversion of a wide range of primary, secondary even tertiary alcohols to the corresponding iodides have been achieved under ionic liquid conditions. The method involves preparation of ionic liquid-based iminium chloride intermediate from DMF-like ionic liquid then stirring it with alcohol in present of sodium iodide. The higher yields of alkyl iodides were obtained w...