A clinical study of vernal keratoconjunctivitis in black children in Southern Africa was conducted to report on the peculiar, predominantly limbal form of the disease, and to test its response to therapy. Pigmented and thickened limbal conjunctiva gave the disease its typical appearance. In severe cases these lesions were encroaching on to the cornea and threatened sight. Placebo had no effect ...

These results in a few patients suggest that doxantrazole may be valuable in the treatment of asthma. A similar protection against asthma induced by allergen challenge has been reported for the orally administered compound AH 7725,3 but the value of disodium cromoglycate was proved by long-term trials4 rather than such singledose studies. Further clinical trials are obviously needed to establis...

In this randomized, double-blind, placebo controlled study, the effect of prior inhalation of nebulized sodium cromoglycate (SCG) (7.3 +/- 0.6 mg) and nedocromil sodium (NED) (7.5 +/- 0.6 mg) was observed on adenosine 5'-monophosphate (AMP)-induced bronchoconstriction in 11 non-atopic asthmatic subjects. The geometric mean provocation doses of methacholine and AMP required to produce a 20% decr...

Evaluation of the effect of hydroalcoholic extracts of Cassia occidentalis in mast cell degradation induced by clonidine in Rats. The effect of oral administration of hydroalcoholic extract of Cassia occidentalis leaves on clonidine induced mast cell degradation has been studied and is compared with the effect of oral administration of Sodium cromoglycate as standard on rats. A clonidine result...

Vernal keratoconjunctivitis (VKC) is usually considered as an allergic eye disorder of type I, and in most therapeutic trials it has been shown to yield to topical treatment with sodium cromoglycate. This has been confirmed in the present study of VKC patients from Israel. However, some of the cases seemed not to benefit from this treatment. In a survey of IgE levels in VKC patients in Israel t...