Inductively coupled plasma mass spectrometry (ICP-MS) has been traditionally employed in life sciences for total element content and speciation studies. Nonetheless, using element-tagged antibodies, ICP-MS also serves as a detector immunoassays thus allowing the determination of organic molecules (i.e. proteins, biomarkers, toxins, etc.) cells. When compared to conventional immunoassay detectio...

Vaccines are a promising but still experimental treatment for melanoma. They are intended to stimulate immune responses against melanoma and by so doing, increase resistance against and slow the progression of this cancer. Key requirements for vaccines to be effective are that they contain antigens that can stimulate tumor-protective immune responses and that some of these antigens are present ...

The story began on 11th May 1857 when Charles Locock commented in the Lancet on his use of potassium bromide in 15 cases of "hysterical" epilepsy in young women. The next development was the serendipitous discovery of the anticonvulsant properties of phenobarbital by Alfred Hauptmann in 1912. This predated by more than 20 years the screening of potential therapeutic agents against "electrical s...

Phishing attacks are becoming an everyday threat to the ever growing cyber community. Regrettably, most online users do not understand some of the simplest indicators of a typical phishing scam. In addition, the sophistication of some of the newest phishing defeat most of the current software-based countermeasure and anti-phishing education. In this work, a new paradigm-shift architecture is pr...

The Role of Thrombophilias Pregnancy is a hypercoagulable state. The field of thrombophilia, the tendency to thrombosis, has been developed rapidly and has been linked to many aspects of pregnancy. Recently, it has been determined that severe pregnancy complications such as severe preeclampsia intrauterine growth retardation (IUGR), abruptio placentae, and intrauterine fetal death (IUFD) are as...

During the last years a growing body of literature studied Linked Data Cubes. The objective of this paper is to accumulate this body of knowledge and provide a preliminary analysis of the research results in the area so far. Towards this end, we systematically reviewed the scientific literature to identify relevant studies. These studies were analysed and synthesised in the form of a proposed c...

The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle development, limb morphogenesis and the specification of different neuronal cell types. In addition, the aberrant activation of the Hedgehog pathway has been identified as the likely cause...