background: celiac disease (cd) is a small bowel enteropathy caused by permanent wheat gluten intolerance. one of the earliest signs of the mucosal immune activation in cd is an increase in the intestinal intraepithelial lymphocytes (iiels) count in the small intestinal epithelium. although most of those iiels express ??tcr, cd is characterized by an increase in the gdtcr + iiels. objective: th...

We present a case of gastric and intestinal Crohn's disease associated with extra-intestinal manifestations of fever, rash in the lower limbs in a 12 years old boy. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) was performed for the diagnosis of the disease causing fever of unknown origin. Gastroscopy showed polypoid hyperplasia and ulcers in...

BACKGROUND Defects in the small intestinal epithelial barrier have been associated with inflammatory bowel disease but their role in the causation of disease is still a matter of debate. In some models of disease increased permeability appears to be a very early event. The interleukin 10 (IL10) gene-deficient mouse spontaneously develops colitis after 12 weeks of age. These mice have been shown...

The aetiological relationship of wheat gluten and gliadin, and some peptides obtained from them by peptic-tryptic digestion, to the clinical and small intestinal mucosal abnormalities of coeliac disease has been demonstrated in several studies (Dicke, 1950; Anderson, Frazer French, Gerrad, Sammons, and Smellie, 1952; Sheldon and Lawson, 1952; Dicke, Weijers, and van de Kamer, 1953; van de Kamer...